Breast carcinoma or sweat gland carcinoma? A report of two cases and a comparison with the literature
Abstract
Primary apocrine carcinoma of the sweat gland is a neoplasm with a very low incidence that may represent a clinical and histological diagnostic challenge, as well as for adequate local, adjuvant, and advanced disease management. The average age of patients is around 67 years with no gender preference. This cancer develops primarily at the axillary and scalp levels and is clinically characterized by slow growth, but can progress aggressively with local, nodal, and metastatic involvement (primarily lung, liver, and bone). The recommended management, once the histology is established, consists of a wide local resection with a clear margin of 1 to 2 cm and regional lymphadenectomy if clinically positive nodes are detected. The adjuvant treatment (radiotherapy or chemotherapy) and for the advanced disease is not established.
We report here the cases of two female patients initially diagnosed with breast cancer who were finally diagnosed with apocrine carcinoma of the sweat gland.
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References
Gatti AP, Tonello L, Pfaffenzeller W, Savóia FO, Goergen DI, De Pieri Coan R, et al. Apocrine sweat gland adenocarcinoma: A rare case report and review. Int J Surg Case Rep. 2017;36:78-81. https://doi.org/10.1016/j.ijscr.2017.04.0
Jandali DB, Ganti A, Al-Khudari S, Tajudeen BA, Revenaugh PC. Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers. Am J Otolaryngol. 2019;40:110-14. https://doi.org/10.1016/j.amjoto.2018.09.011
Wauer U, Sellei R, Zoga E, Braun S, Lorenz D. Atypical course of an apocrine sweat gland carcinoma: A very rare malignant tumor and his interdisciplinary treatment. SM J Case Rep. 2017;3:1052.
Brenn T. Do not break a sweat: Avoiding pitfalls in the diagnosis of sweat gland tumors. Mod Pathol. 2019;33:25-41. https://doi.org/10.1038/s41379-019-0377-7
Ahn CS, Sangüeza OP. Malignant sweat gland tumors. Hematol Oncol Clin North Am. 2019;33:53-71. https://doi.org/10.1016/j.hoc.2018.09.002
Paties C, Taccagni GL, Papotti M, Valente G, Zangrandi A, Aloi F. Apocrine carcinoma of the skin. A clinicopathologic, immunocytochemical, and ultrastructural study. Cancer. 1993;71:375-81. https://doi.org/10.1002/1097-0142(19930115)71:2<375::aid-cncr2820710218>3.0.co;2-4
Le LP, Dias-Santagata D, Pawlak AC, Cosper AK, Nguyen AT, Selim MA, et al. Apocrineeccrine carcinomas: molecular and immunohistochemical analyses. PLoS ONE 2012;7:e47290. https://doi.org/10.1371/journal.pone.0047290
Imamovic D, Bilalovic N, Skenderi F, Beslagic V, Ceric T, Hasanbegovic B, et al. A clinicopathologic study of invasive apocrine carcinoma of the breast: A single-center experience. Breast J. 2018;24:1105-8. https://doi.org/10.1111/tbj.13140
Zembowicz A, García CF, Tannous ZS, Mihm MC, Koerner F, Pilch BZ. Endocrine mucinproducing sweat gland carcinoma. Am J Surg Pathol. 2005;29:1330-9. https://doi.org/10.1097/01.pas.0000170348.40057.60
Agni M, Raven ML, Bowen RC, Laver NV, Chevez-Barrios P, Milman T, et al. An update on endocrine mucin-producing sweat gland carcinoma. Am J Surg Pathol. 2020;44:1005-16. https://doi.org/10.1097/PAS.0000000000001462
Warkel RL. Apocrine gland adenoma and adenocarcinoma of the axilla. Arch Dermatol. 1978;114:198-203. https://doi.org/10.1001/archderm.1978.01640140016004
Kazakov DV, McKee PH, Michal M, Kacerovska D. Cutaneous adnexal tumors. First edition. Philadelphia: Lippincott Williams & Wilkins Health; 2012. p. 830.
Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumors. Fourth edition. Lyon: International Agency for Research on Cancer, World Health Organization, International Academy of Pathology; 2018. p. 470.
Suyama T, Yokoyama M, Nishimura T, Kobayashi K, Katagiri K. Sweat gland carcinoma of the left axilla with disseminated carcinomatosis of the bone marrow. Int J Dermatol. 2020;59:e281-4. https://doi.org/10.1111/ijd.14854
Hollowell KL, Agle SC, Zervos EE, Fitzgerald TL. Cutaneous apocrine adenocarcinoma: Defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. J Surg Oncol. 2012;105:415-9. https://doi.org/10.1002/jso.22023
Al-Hakami H, Awad BI, Al-Garni M, Al-Maghrabi HA, Al-Shareef N. Apocrine carcinoma of the scalp with neck lymph node metastasis: A case report and review of the literature. J Family Med Prim Care. 2019;8:3758-62 https://doi.org/10.4103/jfmpc.jfmpc_833_19
Chamberlain RS, Huber K, White JC, Travaglino-Parda R. Apocrine gland carcinoma of the axilla: Review of the literature and recommendations for treatment. Am J Clin Oncol. 1999;22:131-5. https://doi.org/10.1097/00000421-199904000-00005
Seong MK, Kim EK, Han K, Seol H, Kim HA, Noh WC. Primary apocrine sweat gland carcinomas of the axilla: A report of two cases and a review of the literature. World J Surg Oncol. 2015;13:59. https://doi.org/10.1186/s12957-015-0473-1
Meattini I, Pezzulla D, Saieva C, Bernini M, Orzalesi L, Sánchez LJ, et al. Triple negative apocrine carcinomas as a distinct subtype of triple negative breast cancer: A case-control study. Clin Breast Cancer. 2018;18:e773-80. https://doi.org/10.1016/j.clbc.2018.02.012
Miller DH, Peterson JL, Buskirk SJ, Vallow LA, Ta R, Joseph R, et al. Management of metastatic apocrine hidradenocarcinoma with chemotherapy and radiation. Rare Tumors. 2015;7:13335. https://doi.org/10.4081/rt.2015.6082
Fujisawa Y, Fujimoto M. Metastatic cutaneous apocrine carcinoma of the axilla successfully treated using systemic chemotherapy with i.v. epirubicin and cyclophosphamide followed by oral fluorinated pyrimidine. J Dermatol. 2014;41:280-2. https://doi.org/10.1111/1346-8138.12414
Goldstein R, Stefanato CM, Warbey V, Harries M. Advanced vulvar apocrine carcinoma expressing estrogen receptors that responds to tamoxifen therapy. Future Oncol. 2012;8:1199-203. https://doi.org/10.2217/fon.12.94
Daniel SJ, Nader R, Kost K, Hüttner I. Facial sweat gland carcinoma metastasizing to neck nodes: A diagnostic and therapeutic challenge. Arch Otolaryngol Head Neck Surg. 2001;127:1495-8. https://doi.org/10.1001/archotol.127.12.1495
Hicham T, Mohammed B, Naoufa H. Primary cutaneous apocrine carcinoma with distant metastasis. J Cancer Clin Trials. 2018;3:2. https://doi.org/10.4172/2577-0535.1000145
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