First part. A 45-year-old man with severe pneumonia, disseminated cytomegalovirus infection, and agammaglobulinemia

Mónica Fernandes Pineda, Andrés F. Zea-Vera, .

Keywords: Agammaglobulinemia, cytomegalovirus, pneumonia, adult

Abstract

A 45-year-old male patient presented with a persistent cough lasting four months, accompanied by fever and significant weight loss.
A chest computed tomography revealed cryptogenic pneumonia, and subsequent investigations identified a positive cytomegalovirus (CMV) viral load in bronchoalveolar lavage. A transbronchial biopsy confirmed intranuclear basophilic inclusions indicative of CMV infection. Additionally, blood tests returned positive results for CMV. Immunoglobulin levels revealed IgA < 0.13, IgG < 3, IgM < 0.25 (g/L). Bone marrow biopsy indicated an 80% hypercellularity without morphological alterations. Additional studies for agammaglobulinemia were asked for.

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  • Mónica Fernandes Pineda Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia https://orcid.org/0000-0003-4891-543X
  • Andrés F. Zea-Vera Departamento de Microbiología, Facultad de Salud, Universidad del Valle, Cali, Colombia; Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA https://orcid.org/0000-0001-9127-3677
How to Cite
1.
Fernandes Pineda M, Zea-Vera AF. First part. A 45-year-old man with severe pneumonia, disseminated cytomegalovirus infection, and agammaglobulinemia. Biomed. [Internet]. 2024 Dec. 23 [cited 2025 Apr. 3];44(Sp. 2):48-50. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/7524

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Published
2024-12-23
Section
Make your own diagnosis

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