Location of the repetitive sequence PFCOL692 in genomic fragments of Plasmodium falciparum
Keywords:
Plasmodium falciparum, repetitive sequences, subtelomeric region
Abstract
In this paper we established the subtelomeric localization of the repetitive sequence PFCOL692 of Plasmodium falciparum by the characterization of four clones from a hEMBL41 PFCOL692 genomic library, which contains 15-23Kbp long inserts of parasite genomic DNA. Characterization was made by restriction analysis and the PFCOL692 localization in the genome was explored using specific probes for telomeric (pTB4.1) and subtelomeric regions (pRep20) of P falciparum chromosomes. We proposed a possible organization for the parasite chromosomes ends, where the copies of PFCOL692 are clusters in the subtelomeric region and their localization is conserved with respect to the pRep20 sequence. In addition, we established that PFCOL692 is not located next to the telomere.Downloads
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How to Cite
1.
Alvarado ME, Rojas MO, Guerrero HY, Wasserman M. Location of the repetitive sequence PFCOL692 in genomic fragments of Plasmodium falciparum. Biomed. [Internet]. 2000 Mar. 1 [cited 2025 Apr. 6];20(1):49-58. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/1047
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Published
2000-03-01
Issue
Section
Original articles
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