Clinical and sociodemographic features and quality of life in patients with atopic dermatitis who attended dermatology teaching clinics in Medellín, Antioquia and its metropolitan area
Abstract
Introduction: Atopic dermatitis is a cutaneous, inflammatory, chronic disease, very frequent in the world and it imposes a high clinical and quality of life impact in patients. To date there are no local studies describing the general features in our population.
Objective: To evaluate the socio demographic, clinical and life quality features in patients with atopic dermatitis from Medellín city and its metropolitan area.
Materials and methods: cross sectional, descriptive study, that included patients who attended some teaching dermatological clinics. Data collection included sociodemographic and clinical features in addition to clinical issues and quality of life measurements.
Results: A total of 13 patients were included. 36,3% manifested a sleeping disturbance, 38,1% attention deficit; 44,2% reported asthma in the childhood. EASI and SCORAD scores were 6,9 and 32,4, respectively, which indicates a mild-moderate compromise. Regarding quality of Life, Skindex-29 showed average scores for the symptomatic, emotional and functional dominions of 37,7, 25,09 and 16,9, respectively, and a total score of 24,78. In EQ-5D scores, the most altered component was the presence of pain or discomfort (17,6%) and the presence of anxiety or depression (12,1%), which enhances the symptomatic and emotional impact of the disease.
Conclusion: These results confirm that patients with atopic dermatitis present similar features to those reported in other studies from different countries, highlighting the burden of the disease in adults and its impact in neuropsychiatric and emotional domains.
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References
Wallach D, Taïeb A. Atopic dermatitis/atopic eczema. Chem Immunol Allergy. 2014;100:81-96. https://doi.org/10.1159/000358606
McPherson T. Current understanding in pathogenesis of atopic dermatitis. Indian J Dermatol. 2016;61:649-55. https://doi.org/10.4103/0019-5154.193674
Sullivan M, Silverberg NB. Current and emerging concepts in atopic dermatitis pathogenesis. Clin Dermatol. 2017;35:349-53. https://doi.org/10.1016/j.clindermatol.2017.03.006
Busi FM. Barrera epidérmica en dermatitis atópica. Rev Asoc Colomb Dermatología. 2008;16:293-301.
Kirchhof MG, Landells I, Lynde CW, Gooderham MJ, Hong CH. Approach to the assessment and management of adult patients with atopic dermatitis: A consensus document. Section I: Pathophysiology of atopic dermatitis and implications for systemic therapy. J Cutan Med Surg. 2018;22:6S-9S. https://doi.org/10.1177/1203475418803626
Silverberg JI, Simpson EL. Associations of childhood eczema severity: A US populationbased study. Dermatitis. 2014;25:107-14. https://doi.org/10.1097/DER.0000000000000034
Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol. 2009;124:1251-58.e23. https://doi.org/10.1016/j.jaci.2009.10.009
Dennis R, Caraballo L, García E, Caballero A, Aristizábal G, Córdoba H, et al. Asthma and other allergic conditions in Colombia: A study in 6 cities. Ann Allergy Asthma Immunol. 2004;93:56-74. https://doi.org/10.1016/S1081-1206(10)61265-3
Dennis RJ, Caraballo L, García E, Rojas MX, Rondón MA, Pérez A, et al. Prevalence of asthma and other allergic conditions in Colombia 2009 - 2010: A cross-sectional study. BMC Pulm Med. 2012;12:1-9. https://doi.org/10.1186/1471-2466-12-17
Ezzedine K, Kechichian E. Épidémiologie de la dermatite atopique. Ann Dermatol Venereol. 2017;144:VS4-7. https://doi.org/10.1016/S0151-9638(18)30085-1
Catalina S, Restrepo M, Mejía CC, William J, Ochoa C. Prevalencia de alergias en niños entre 5 y 14 años con trastorno de déficit de atención e hiperactividad. Medellín, 2012. Acta Neurológica Colomb. 2014;30:156-62.: http://www.scielo.org.co/pdf/anco/v30n3/v30n3a05.pdf
Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387:1109-22. https://doi.org/10.1016/S0140-6736(15)00149-X
Thomsen SF. Atopic dermatitis: Natural history, diagnosis, and treatment. ISRN Allergy. 2014;2014:354250. https://doi.org/10.1155/2014/354250
Rivero JI. Dermatitis atópica. Rev Médica Costa Rica y Centroamérica. 2016;LXXIII(620):711-6.
DaVeiga SP. Epidemiology of atopic dermatitis: A review. Allergy Asthma Proc 2012;33:227-34. https://doi.org/10.2500/aap.2012.33.3569
Tagani H. Japanese Dermatological Association criteria for the diagnosis of atopic dermatitis. J Dermatol. 2014;29:398. https://doi.org/10.1111/j.1346-8138.2002.tb00292.x
Hanifin JM, Cooper KD, Ho VC, Kang S, Krafchik BR, Margolis DJ, et al. Guidelines of care for atopic dermatitis. J Am Acad Dermatol. 2004;50:391-404. https://doi.org/10.1016/j.jaad.2003.08.003
Vakharia PP, Chopra R, Silverberg JL. Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials. Am J Clin Dermatol. 2018;19:15-22. https://doi.org/10.1007/s40257-017-0299-4
Sanclemente G, García H, Aguirre D, Jones M, Lugo L, Escobar C, et al. Fiabilidad y validez de constructo de la versión colombiana del instrumento de calidad de vida Skindex-29© en Medellín, Colombia. Iatreia. 2017;30:21-33.
Tofte S, Graeber M, Cherill R, Omoto M, Thurston M, Hanifin JM. Eczema area and severity index (EASI): A new tool to evaluate atopic dermatitis. J Eur Acad Dermatology Venereol. 1998;11:S197. https://doi.org/10.1016/S0926-9959(98)95291-6
Boguniewicz M, Fonacier L, Guttman-Yassky E, Ong PY, Silverberg J, Farrar JR. Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape. Ann Allergy Asthma Immunol. 2018;120:10-22.e2. https://doi.org/10.1016/j.anai.2017.10.039
Atherton DJ, Bieber T, Bonifazi E, Broberg A, Calza A, Coleman R, et al. Severity scoring of atopic dermatitis: The SCORAD index. Dermatology. 1993;186:23-32. https://doi.org/10.1159/000247298
Sanclemente G, Burgos C, Nova J, Hernández F, González C, Reyes MI, et al. The impact of skin diseases on quality of life: A multicenter study. Actas Dermo-Sifiliográficas. 2017;108:244-52. https://doi.org/10.1016/j.adengl.2016.11.019
Herdman M, Badia X, Berra S. El EuroQol-5D: una alternativa sencilla para la medición de la calidad de vida relacionada con la salud en atención primaria. Atención Primaria. 2001;28:425-9.
Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatology Venereol. 2018;32:657-82. https://doi.org/10.1111/jdv.14891
Sy W, Lamb AJ. Atopic dermatitis disease education. In: Fortson EA, et al., editor. Management of atopic dermatitis, advances in experimental medicine and biology. 1st edition. New York: Springer International Publishing; 2017. p. 179-84.
Dhadwal G, Albrecht L, Gniadecki R, Poulin Y, Yeung J, Hong CH, et al. Approach to the assessment and management of adult patients with atopic dermatitis: A consensus document. Section IV: Treatment options for the management of atopic dermatitis. J Cutan Med Surg. 2018;22:21S-9S. https://doi.org/10.1177/1203475418803627
Calzavara P, Cristaudo A, Foti C, Canonica GW, Balato N, Costanzo A, et al. Diagnosis and management of moderate to severe adult atopic dermatitis: A consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Italian Association of Hospital Dermatologists (ADOI), the Italian Society of Allergy, Asthma and Cli. G Ital Dermatol Venereol. 2018;153:13345. https://doi.org/10.23736/S0392-0488.17.05892
González P, Lázaro M, Llaneza J, Luca de T Á, Ortiz JM, Palacios D, et al. Informe Grupo de Trabajo Dermatitis atópica: del diagnóstico a la definición de una ruta asistencial. Madrid: Fundamed; 2019. p. 1-40.
Sanclemente G, Mahecha M, Guzmán C. Enfermedades de la piel más frecuentes en la consulta dermatológica del Hospital Universitario San Vicente de Paúl y del Hospital Infantil Medellín, 1999. Acta Médica Colomb. 2001;26:240-5.
Pyun BY. Natural history and risk factors of atopic dermatitis in children. Allergy Asthma Immunol Res. 2014;7:101-5. https://doi.org/10.4168/aair.2015.7.2.101
Silverberg JL. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123:144-51. https://doi.org/10.1016/j.anai.2019.04.020
Davis DM, Waldman A, Jacob S, LeBovidge J, Ahluwalia J, Tollefson M, et al. Diagnosis, comorbidity, and psychosocial impact of atopic dermatitis. Semin Cutan Med Surg. 2017;36:95-9. https://doi.org/10.12788/j.sder.2017.028
Paller A, Jaworski JC, Simpson EL, Boguniewicz M, Russell JJ, Block JK, et al. Major comorbidities of atopic dermatitis: Beyond allergic disorders. Am J Clin Dermatol. 2018;19:821-38. https://doi.org/10.1007/s40257-018-0383-4
Andersen YMF, Egeberg A, Skov L, Thyssen JP. Comorbidities of atopic dermatitis: Beyond rhinitis and asthma. Curr Dermatol Rep. 2017;6:35-41. https://doi.org/10.1007/s13671-017-0168-7
Ravn NH, Halling AS, Berkowitz AG, Rinnov MR, Silverberg JI, Egeberg A, et al. How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis. J Allergy Clin Immunol. 2020;145:1182-93. https://doi.org/10.1016/j.jaci.2019.12.899
Böhme M, Wickman M, Nordvall SL, Svartengren M, Wahlgren CF. Family history and risk of atopic dermatitis in children up to 4 years. Clin Exp Allergy. 2003;33:1226-31. https://doi.org/10.1046/j.1365-2222.2003.01749.x
Sicras-Mainar A, Navarro-Artieda R, Carrascosa-Carrillo JM. Impacto económico de la dermatitis atópica en adultos: estudio de base poblacional (estudio IDEA). Actas Dermosifiliogr. 2018;109:35-46. https://doi.org/10.1016/j.ad.2017.09.003
Chopra R, Vakharia PP, Sacotte R, Patel N, Immaneni S, White T, et al. Severity strata for Eczema Area and Severity Index (EASI), modified EASI, Scoring Atopic Dermatitis (SCORAD), objective SCORAD, Atopic Dermatitis Severity Index and body surface area in adolescents and adults with atopic dermatitis. Br J Dermatol. 2017;177:1316-21. https://doi.org/10.1111/bjd.15641
Chu H, Shin JU, Park CO, Lee H, Lee J, Lee KH. Clinical diversity of atopic dermatitis: Review of 5,000 patients with atopic dermatitis at a single institute. Allergy Asthma Immunol Res. 2017;9:158-68. https://doi.org/10.4168/aair.2017.9.2.158%0Ahttp://e-aair.org
Adegbidi H, Akpadjan F, Atadokpede F, Degboe B, Agbessi N, Koudoukpo C, et al. Stigmata of atopy in children in Dermatology-Venereology Department of National University Hospital Center Hubert Koutoukou Maga of Cotonou. Skin Dis Skin Care. 2017;23:3-5.
Przybilla B, Bauer C. Stigmata of the atopic constitution. In: Ring J, Przybilla B, Ruzicka T, editors. Handbook of the atopic eczema. Berlin: Springer; 2006. p. 61-73.
Nankervis H, Thomas KS, Delamere FM, Barbarot S, Rogers NK, Williams HC. Scoping systematic review of treatments for eczema. Program Grants Appl Res. 2016;4:1-480. https://doi.org/10.3310/pgfar04070
Gooderham MJ, Hong HC ho, Eshtiaghi P, Papp KA. Dupilumab: A review of its use in the treatment of atopic dermatitis. J Am Acad Dermatol. 2018;78:S28-36. https://doi.org/10.1016/j.jaad.2017.12.022
Eguíluz-Gracia I, Robledo-Echarren T, Suárez-Fernández R, Fernández-Rivas M, Sánchez-Ramón S. Omalizumab for the treatment of atopic dermatitis. Clin Investig (Lond). 2015;5:121-36. https://doi.org/10.4155/CLI.14.108
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