Cutaneous leishmaniasis and pregnancy
Abstract
We studied a 19-year-old woman, with a 4-month pregnancy who presented with four cutaneous leg ulcers of three months of evolution diagnosed by biopsy as cutaneous leishmaniasis. Direct smear and the leishmanin skin test were negative.
Since all the usual medications for cutaneous leishmaniasis are contraindicated in pregnancy, she did not receive any treatment but cured spontaneously of her lesions during pregnancy. It is believed that cutaneous leishmaniasis does not carry danger for pregnant women and that there is no maternal-fetal transmission in humans, though it occurs in experimental animals.
The patient gave birth without complications and both she and her son remained normal after two years of follow-up.
Downloads
References
Rodríguez G, Arenas C, Ovalle C, Hernández CA, Camargo C. Las leishmaniasis. Atlas y texto. Bogotá: Centro Dermatológico Federico Lleras Acosta; 2016.
Organización Panamericana de la Salud - Organización Mundial de la Salud. Informe Leishmaniasis No 4, julio 2016. Ginebra; OPS: 2016.
Instituto Nacional de Salud. Boletín Epidemiológico Semanal. Semana epidemiológica número 52 de 2016. 25 de diciembre - 31 de diciembre, 2016. Bogotá: Instituto Nacional de Salud; 2016. Fecha de consulta: 14 de julio de 2017. Disponible en: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2016%20Bolet%C3%ADn%20
epidemiol%C3%B3gico%20semana%2052%20-.pdf
Vélez ID, Hendrickx E, Robledo SM, Agudelo SM. Leishmaniosis cutánea en Colombia y género. Cad Saúde Pública. 2001;17:171-81. https://doi.org/10.1590/S0102-311X2001000100018
Morgan DJ, Guimaraes LH, Machado PR, D´Oliveira Jr A, Almeida RP, Lago EL, et al. Cutaneous leishmaniasis during pregnancy: Exhuberant lesions and potential fetal complications. Clin Infect Dis. 2007;45:478-82. https://doi.org/10.1086/520017
Conceicao-Silva F, Morgado FN, Pimentel FM, Vasconcellos EC, Schubach AO, Valete-Roselino CM, et al. Two women presenting worsening cutaneous ulcers during pregnancy: Diagnosis, immune response, and follow-up. PLoS Negl Trop Dis. 2013;7:e2472. https://doi.org/10.1371/journal.pntd.0002472
Berger BA, Bartlett AH, Saravia NG, Galindo SN. Pathophysiology of Leishmania infection during pregnancy. Trends Parasitol. 2017;33:935-46. https://doi.org/10.1016/j.pt.2017.08.012
Ávila-García M, Mancilla-Ramírez J, Segura-Cervantes E, Farfán-Labone B, Ramírez-Ramírez A, Sevilla-Galindo N. Transplacental transmission of cutaneous Leishmania mexicana strain in BALB/c mice. Am J Trop Med Hyg. 2013;89:354-8. https://doi.org/10.4269/ajtmh.12-0716
Osorio Y, Rodríguez LD, Bonilla Dl, Peniche AG, Henao H, Saldarriaga O, et al. Congenital transmission of experimental leishmaniasis in a hamster model. Am J Trop Med Hyg. 2012;86:812-20. https://doi.org/10.4269/ajtmh.2012.11-0458
Rodríguez-Barraquer I, Góngora R, Prager M, Pacheco R, Montero LM, Navas A, et al. Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia. Am J Trop Med Hyg 2008;78:276-82.
Pagliano P, Carannante N, Rossi M, Gramiccia M, Gradoni L, Faella FS, et al. Visceral leishmaniasis in pregnancy: A case series and a systematic review of the literature. J Antimicrobial Chem. 2005;55:229-33. https://doi.org/10.1093/jac/dkh538
Turine-Neto P, Figueiró-Fihlo E, Oliveira V, Coehlo L, Breda I, Melo L, et al. Visceral leishmaniasis and pregnancy: A retrospective study of cases reported in Brazil. Int J Gynecol Obstet. 2009;107(Suppl.2):S364. https://doi.org/10.1016/S0020-7292(09)61326-6
Fontenele SJ, Freire GT, Gomes PM, Tolentino SM. Treatment of American tegumentary leishmaniasis in special populations: A summary of evidence. Rev Soc Bras Med Trop. 2013;46:669-77. https://doi.org/10.1590/0037-8682-0104-2013
Layegh P, Pezeshkpoor F, Soruri AH, Naviafar P, Moghiman T. Efficacy of cryotherapy versus intralesional meglumine antimoniate (Glucantime) for treatment of cutaneous leishmaniasis in children. Am J Trop Meg Hyg. 2009;80:172-5.
Vega JC, Sánchez BF, Montero LM, Montaña R, Mahecha MP, Dueñas B, et al. The efficacy of thermotherapy to treat cutaneous leishmaniasis in Colombia. A comparative observational study in an operational setting. Trans R Soc Trop Med Hyg. 2009;103:703-6. https://doi.org/10.1016/j.trstmh.2008.10.039
López L, Robayo M, Vargas M, Vélez ID. Thermotherapy. An alternative for the treatment of American cutaneous leishmaniasis. Trials. 2012;13:58. https://doi.org/10.1186/1745-6215-13-58
Sundar S, Chakravarty J, Agarwai D, Rai M, Murray HW. Single-dose liposomal amphotericin B for visceral leishmaniasis in India. N Engl J Med 2010;362:604-12. https://doi.org/10.1056/NEJMoa0903627
Some similar items:
- Luis Miguel Sosa, Luz Libia Cala, Julio César Mantilla, Congenital tuberculosis associated with maternal disseminated miliary tuberculosis , Biomedica: Vol. 27 No. 4 (2007)
- Juan Gabriel Piñeros, Malaria and social health determinants: a new heuristic framework from the perspective of Latin American social medicine , Biomedica: Vol. 30 No. 2 (2010)
- Rafael José Vivero, Maria Angélica Contreras-Gutiérrez, Eduar Elías Bejarano, Analysis of the primary and secondary structure of the mitochondrial serine transfer RNA in seven species of Lutzomyia , Biomedica: Vol. 27 No. 3 (2007)
- Elsa Nieves, Neudo Buelvas, Maritza Rondón, Néstor González, The salivary glands of two sand fly vectors of Leishmania: Lutzomyia migonei (França) and Lutzomyia ovallesi (Ortiz) (Diptera: Psychodidae) , Biomedica: Vol. 30 No. 3 (2010)
- Carlos Pérez, Yoanet Solías, Gerzaín Rodríguez, Diffuse cutaneous leishmaniasis in a patient with AIDS , Biomedica: Vol. 26 No. 4 (2006)
- María Angélica Contreras, Rafael José Vivero, Eduar Elías Bejarano, Lina María Carrillo, Iván Darío Vélez, New records of phlebotomine sand flies (Diptera: Psychodidae) near the Amoya River in Chaparral, Tolima , Biomedica: Vol. 32 No. 2 (2012)
- Luz Adriana Acosta, Karina Mondragon-Shem, Daniela Vergara, Andrés Velez-Mira, Horacio Cadena, Lina Maria Carrillo, Expansion of the distribution of Lutzomyia longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae) in the department of Caldas: increased risk of visceral leishmaniasis , Biomedica: Vol. 33 No. 2 (2013)
- Stella Carrasco Rodríguez, Myriam Sanchez Gómez, Serum IGF-I and IGFBP-3 levels in pregnant adolescents in an economically depressed community , Biomedica: Vol. 21 No. 4 (2001)
- Berta N. Restrepo, Diana M. Isaza, Clara L. Salazar, José L. Ramírez, Gloria E. Upegui, Marta Ospina, Ruth Ramírez, Prenatal and postnatal effects of dengue infection during pregnancy. , Biomedica: Vol. 23 No. 4 (2003)
- Clemencia Ovalle-Bracho, Carolina Camargo, Yira Díaz-Toro, Marcela Parra-Muñoz, Molecular typing of Leishmania (Leishmania) amazonensis and species of the subgenus Viannia associated with cutaneous and mucosal leishmaniasis in Colombia: A concordance study , Biomedica: Vol. 38 No. 1 (2018)
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |










