Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention.
Keywords:
Mycobacterium tuberculosis, gene inactivation, functional genomic, attenuated mutants
Abstract
Availability of the M. tuberculosis genome sequence and the development of sophisticated systems for genetic manipulation of bacilli offer the potential for new and effective tools to prevent and control tuberculosis. Efficient methods to inactivate mycobacterial genes have been developed. These methods have become the cornerstone for the application and development of mycobacterial functional genomics. Specific mutants are generated to establish the role of targetted genes associated with mycobacterial physiology and pathogenesis. Gene inactivation, supported directly or indirectly by the deciphering of the mycobacterial genome, has permitted the generation of large numbers of M. tuberculosis mutants. Analysis of these mutants has (in some cases) established relationships between gene products and their role in mycobacterial physiology and pathogenesis.Downloads
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How to Cite
1.
Chacón O, Realpe T, Barletta RG, Robledo J. Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention. Biomed. [Internet]. 2004 Jun. 1 [cited 2025 Apr. 12];24(Sup1):165-87. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/1316
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Published
2004-06-01
Section
Topic review
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