Sternal osteomyelitis and scrofuloderma due to BCG vaccination.
Keywords:
mycobacterium bovis, BCG vaccine adverse effects, osteomyelitis, microbiology
Abstract
BCG vaccine has been used for nearly 100 years in the prevention of tuberculosis. The case of a 13 month-old girl vaccinated as a newborn with BCG is described as presenting a sternal mass with associated periostic erosion. The mass was resected, and histopathological examination revealed a chronic inflammatory reaction with caseous granulomas, and extension to bone and skin. PCR amplifications using specific primers for Mycobacterium tuberculosis on paraffin-embedded tissue were negative. BCG vaccination at birth, the histological appearance and the absence of M. tuberculosis DNA in the resected tissue indicated that osteomyelitis and scrofuloderma were a consequence of BCG. Osteomyelitis is a rarely occurring adverse effect of BCG vaccination, more commonly seen in immunosuppressed patients. In the patient described above, no symptoms of immunodeficiency were seen, however.Downloads
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How to Cite
1.
Corrales IF, Cortés JA, Mesa ML, Zamora G. Sternal osteomyelitis and scrofuloderma due to BCG vaccination. Biomed. [Internet]. 2003 Jun. 1 [cited 2026 Mar. 4];23(2):202-7. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/1212
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Published
2003-06-01
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Section
Case presentation
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