Leptin levels in school age children associated with anthropometric measurements and lipid profiles
Abstract
Introduction. Leptins are proteins that regulate body weight. Their concentrations are modified depending on several factors including metabolic status, diabetes mellitus type 2 and cardiovascular diseases.
Objective. The leptin concentrations were measured in Colombian children and related to age, sex, body mass index, triceps skinfold and lipid profile.
Materials and methods. School age children from 5 provinces of central-eastern Colombia were examined. Measurements included body mass index, body fat reserves, leptin concentrations and lipid profile.
Results. The overall leptin concentrations were 8.3±8.9 ng/ml. The concentrations varied by differences in the age and sex, but were equal in children with higher body weight and greater fat deposition. A positive relationship was observed between high leptin levels and high total cholesterol in males, and in females, an association of high leptin levels with high levels of triglycerides.
Conclusion. The leptin concentrations followed a trend similar to those of other population groups with differences according to the age, sex and deposits of fat mass. However, thevalues seem to be influenced by hormonal differences and food habits. In addition, overweight or obese school children probably have hyperleptinemia, correlated to metabolic syndrome, diabetes mellitus type 2 and cardiovascular diseases. The sex specific association between total cholesterol, triglycerides and leptin suggests a complex relationship that depends on biological and hormonal differences, as well as environmental and life style differences. Each of these associations requires additional focused study for verification.
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References
1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-70.
2. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-9.
3. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000;62:413-37.
4. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med. 1996;334:292-5.
5. Isidori AM, Strollo F, Morè M, Caprio M, Aversa A, Moretti C, et al. Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin Endocrinol Metab. 2000;85:1954-62.
6. Ryan AS, Elahi D. The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity and age in women. J Clin Endocrinol Metab. 1996;81:4433-8.
7. Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R, et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab. 1997;82:579-84.
8. Ahmed ML, Ong KK, Morrell DJ, Cox L, Drayer N, Perry L, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab. 1999;84:899-905.
9. Kirel B. Serum leptin levels during childhood and adolescence: relationship with age, sex, adiposity and puberty. Turk J Pediatr. 1999;41:447-55.
10. Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity and energy expenditure. J Clin Endocrinol Metab. 1997;82:1293-300.
11. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab. 1997;82:2904-10.
12. Brandão CM, Lombardi MT, Nishida SK, Hauache OM, Vieira JG. Serum leptin concentration during puberty in healthy nonobese adolescents. Braz J Med Biol Res. 2003;36:1293-6.
13. Wang S, Yu C, Sun C, Liu Z. Changes and relations of leptin, growth hormone and insulin during puberty in obese and non-obese children. Wei Sheng Yan Jiu. 2001;30:219-20.
14. Sun C, Yu C, Wang S. Study on the effects of leptin on puberty development in children. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35:293-6.
15. Roemmich JN, Rogol AD. Role of leptin during childhood growth and development. Endocrinol Metab Clin North Am. 1999;28:749-64.
16. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 1997;82:2849-55.
17. Falorni A, Bini V, Molinari D, Papi F, Celi F, Di Stefano G, et al. Leptin serum levels in normal weight and obese children and adolescents: relationship with age, sex, pubertal development body mass index and insulin. Int J Obes Relat Metab Disord. 1997;21:881-90.
18. Reiterer EE, Sudi KM, Mayer A, Limbert-Zinterl C, Stalzer-Brunner C, Fuger G, et al. Changes in leptin, insulin and body composition in obese children during a weight reduction program. J Pediatr Endocrinol Metab. 1999;12:853-62.
19. Hassink SG, Sheslow DV, De Lancey W, Openatanova I, Considine RV, Caro J. Serum leptin in children with obesity: relationship to gender an development. Pediatrics. 1996;98:201-3.
20. Savoye M, Dziura J, Castle J, Dipietro L, Tamborlane WV, Caprio S. Importance of plasma leptin in predicting future weight gain in obese children: a twoand a half-year longitudinal study. Int J Obes Relat Metab Disord. 2002;26:942-6.
21. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. 2001;157:495-503.
22. Hirose H, Saito I, Kawai T, Tsujioka M, Kawabe H, Saruta T. Relationships between baseline serum leptin levels and 2-year changes in body mass index pressure and metabolic parameters in japanese male adolescents and middle-aged men. Clin Sci (Lond). 2001;100:145-50.
23. Leyva F, Godsland IF, Ghatei M, Proudler AJ, Aldis S, Walton C, et al. Hyperleptinemia as a component of a metabolic syndrome and of cardiovascular risk. Arterioscler Thromb Vasc Biol. 1998;18:928-33.
24. Stejskal D, Ruzicka V, Horalik D, Jedelsky L, Bartek J, Oral I. Leptinemia in individuals with hypertension (pilot study). Vnitr Lek. 1999;45:206-9.
25. Leiva F, Anker SD, Egerer K, Stevenson JC, Kox WJ, Coats AJ. Hyperleptinemia in chronic heart failure. Relationships with insulin. Eur Heart. 1998;19:1547-51.
26. Soderberg S, Ahren B, Jansson JH, Johnson O, Hallmans G, Asplund K, Olsson T. Leptin is associated with increased risk of myocardial infarction J Intern Med. 1999;246:409-18.
27. Yang NH, Zhou YZ, Mao LM, Huang Y, Qi ZY. Relationship between serum levels of leptin and glucose, lipids in simple obese children. Zhonghua Yu Fang Yi Xue Za Zhi. 2003;37:186-8.
28. Laskowska-Klita T, Ambroszkiewicz J, Weker H, Szymborska M, Klemarczyk W. Serum leptin level in prepubertal children with simple obesity. Part II. Med Wieku Rozwoj. 2002;6:213-20.
29. Kavazarakis E, Moustaki M, Gourgiotis D, Drakatos A, Bossios A, Zeis PM, et al. Relation of serum leptin levels to lipid profile in healthy children. Metabolism 2001;50:1091-4.
30. Wu DM, Shen MH, Chu NF. Relationship between plasma leptin levels and lipid profiles among school children in Taiwan-the Taipei Children Heart Study. Eur J Epidemiol. 2001;17:911-6.
31. Rosner B, Prineas R, Loggie J, Daniels SR. Percentiles for body mass index in U.S. children 5 to 17 years of age. J Pediatr. 1998;132:211-22.
32. Must A, Dallal GE, Dietz WH. Reference data for obesity: 85th and 95th percentiles of body mass index (wt/ht2) and triceps skinfold thickness. Am J Clin Nutr. 1991;53:839-46.
33. Henríquez PG, Hernández Valera Y, Arenas O, Garcia Blanco M, Cardona Y. Valores de IMC (P/T2) para el diagnóstico de la obesidad en niños y adolescentes en Venezuela. En: Manual de Crecimiento
y Desarrollo. Caracas: FUNDACREDESA; 1997. p.186.
34. Henríquez Pérez G, Hernández Valera G, Correa Alfonso C. Evaluación nutricional antropométrica. En: López-Blanco M, Landaeta Jiménez M, editores. Manual de crecimiento y desarrollo. Caracas: Serano-Andina; 1992. p.16-23.
35. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the separative ultracentrifuge. Clin Chem. 1972;18:499-502.
36. National Cholesterol Education Program (NCEP). Higlights of the report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics. 1992;89:495-501.
37. Viso Gonzáles M, Solano R L, Sánchez A, Portillo Z, Llovera D. Leptina sérica en niños y adolescentes venezolanos obesos y eutróficos. ALAN. 2005;55:47-54.
38. Dubey S, Kabra M, Bajpai A, Pandey RM, Hasan M, Gautam RK, et al. Serum leptin levels in obese Indian children relation to clinical and biochemical parameters. Indian Pediatr. 2007;44:257-62.
39. Yang NH, Zhou YZ, Mao LM, Huang Y, Qi ZY. Relationship between serum levels of leptin and glucose, lipids in simple obese children. Zhonghua Yu Fang Yi Xue Za Zhi. 2003;37:186-8.
40. Byrnes SE, Baur LA, Bermingham M, Brock K, Steinbeck K. Leptin and total cholesterol are predictors of weight gain in pre-pubertal children. Int J Obes Relat Metab Disord. 1999;23:146-50.
41. Bertrais S, Balkau B, Charles MA, Vol S, Calvet C, Tichet J, et al. Puberty-associated differences in total cholesterol and triglyceride levels according to sex in French children aged 10-13 years. Ann Epidemiol. 2000;10:316-23.
42. Frerichs RR, Srinivasan SR, Webber LS, Berenson GR. Serum cholesterol and triglyceride levels in 3,446 children from a biracial community: the Bogalusa Heart Study. Circulation. 1976;54:302-9.
43. Bahar A, Sevgican U, Karademir F, Gocmen I. Serum cholesterol, triglyceride, VLDL-c, LDL-c, and HDL-c levels in healthy children. Tohoku J Exp Med. 2003;201:75-80.
44. Zeisel SH, Freake HC, Bauman DE, Bier DM, Burrin DG, German JB, et al. The nutritional phenotype in the age of metabolomics. J Nutr. 2005;135:1613-6.
45. Nicklas TA, Dwyer J, Feldman HA, Luepker RV, Kelder SH, Nader PR. Serum cholesterol levels in children are associated with dietary fat and fatty acid intake. J Am Diet Assoc. 2002;102:511-7.
46. Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocr Metab. 1997;82:4144-8.
47. Morrison JA, Sprecher DL, Biro FM, Apperson-Hansen C, Lucky AW, DiPaola LM. Estradiol and testosterone effects on lipids in black and white boys aged 10 to 15 years. Metabolism. 2000;49:1124-9.
48. Pilcová R, Sulcová J, Hill M, Bláha P, Lisá L. Leptin levels in obese children: effects of gender, weight reduction and androgens. Physiol Res. 2003;52:53-60.
49. Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89:3313-8.
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