Identification of HIV infection in two solid organ recipients three years after transplantation
Abstract
Routine screening of organ donors to detect human immunodeficiency virus (HIV) infection has detected the rare transmission of the virus through organ transplantation. However, despite routine screening, HIV transmission remains a risk in organ transplantation since, unlike tissues, solid organs cannot be processed, disinfected, or modified to inactivate infectious pathogens.
A case of possible transmission of HIV by organ transplant is described below, from a previously seronegative donor to two recipients.
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References
Pirnay JP, Vandenvelde C, Duinslaeger L, Reper P, Vanderkelen A. HIV transmission by transplantation of allograft skin: A review of the literature. Burns. 1997;23:1-5. https://doi.org/10.1016/S0305-4179(96)00081-2
Len O, Pahissa A. Donor-transmitted infections. Enferm Infecc Microbiol Clin. 2007;25:204-12. https://doi.org/10.1016/s0213-005x(07)74262-3
Patijn GA, Strengers PF, Harvey M, Persijn G. Prevention of transmission of HIV by organ and tissue transplantation. HIV testing protocol and a proposal for recommendations concerning donor selection. Transpl Int. 1993;6:165-72. https://doi.org/10.1111/j.1432-2277.1993.tb00640.x
Ministerio de la Protección Social. Decreto número 2493 de 2004. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.minsalud.gov.co/Normatividad_Nuevo/DECRETO%202493%20DE%202004.pdf
Ministerio de Salud y Protección Social, Empresa Nacional Promotora del Desarrollo Territorial e Instituto de Evaluación Tecnológica en Salud. Guía de Práctica Clínica basada en la evidencia científica para la atención de la infección por VIH/SIDA en personas adultas, gestantes y adolescentes. Versión para profesionales de salud. Guía N° 39-2021. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ET/gpc-vih-adultos-version-profesionales-salud.pdf
Coordinación Red Nacional Bancos de Sangre y Servicios de Transfusión. Caso 1-2019:notificación de una infección transmitida por transfusión (ITT)–Virus de Inmunodeficiencia Humana (VIH) identificada por genotipificación. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.ins.gov.co/BibliotecaDigital/notificacion-de-una-itt-vihidentificada-por-genotipificacion.pdf
Ministerio de Salud. Resolución número 8430 de 1993. Por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESOLUCION-8430-DE-1993.pdf
Arias-Murillo YR, Salinas-Nova MA, Molina HF. Manual de biovigilancia de órganos. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.ins.gov.co/BibliotecaDigital/manual-de-biovigilancia-de-organos.pdf
Ministerio de Protección Social. Resolución 002640 de 2005. Por medio de la cual se reglamentan los artículos 3º, 4º, 6º parágrafo 2º, 7º numeral 10, 25 y 46 del Decreto 2493 de 2004 y se dictan otras disposiciones. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.minsalud.gov.co/Normatividad_Nuevo/RESOLUCI%C3%93N%202640%20DE%202005.pdf
Congreso de Colombia. Ley 1805 de 2016 por medio de la cual se modifican la Ley 73 de 1988 y la Ley 919 de 2004 en materia de donación de componentes anatómicos y se dictan otras disposiciones. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.suin-juriscol.gov.co/viewDocument.asp?id=30022839
Ministerio de la Protección Social. Decreto número 2493 de 2004 por el cual se reglamentan parcialmente las Leyes 9ª de 1979 y 73 de 1988, en relación con los componentes anatómicos. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://www.minsalud.gov.co/Normatividad_Nuevo/DECRETO%202493%20DE%202004.pdf
Rubin RH, Tolkoff-Rubin NE. The problem of human immunodeficiency virus (HIV) infection and transplantation. Transpl Int. 1988;1:36-42. https://doi.org/10.1111/j.1432-2277.1988.tb01777.x
Bowen PA 2nd, Lobel SA, Caruana RJ, Leffell MS, House MA, Rissing JP, et al. Transmission of human immunodeficiency virus (HIV) by transplantation: Clinical aspects and time course analysis of viral antigenemia and antibody production. Ann Intern Med. 1988;108:46-8. https://doi.org/10.7326/0003-4819-108-1-46
Simonds RJ. HIV transmission by organ and tissue transplantation. AIDS. 1993;7(Suppl.2):S35-8. https://doi.org/10.1097/00002030-199311002-00008
Centers for Disease Control and Prevention. Guidelines for preventing transmission of human immunodeficiency virus through transplantation of human tissue and organs. MMWR Recomm Rep. 1994;43:1-17.
Donegan E, Stuart M, Niland JC, Sacks HS, Azen SP, Dietrich SL, et al. Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donations. Ann Intern Med. 1990;113:733-9. https://doi.org/10.7326/0003-4819-113-10-733
Colebunders R, Ryder R, Francis H, Nekwei W, Bahwe Y, Lebughe I, et al. Seroconversion rate, mortality, and clinical manifestations associated with the receipt of a human immunodeficiency virus-infected blood transfusion in Kinshasa, Zaire. J Infect Dis. 1991;164:450-6. https://doi.org/10.1093/infdis/164.3.450
Ison MG, Llata E, Conover CS, Friedewald JJ, Gerber SI, Grigoryan A, et al. HIV-HCV Transplantation Transmission Investigation Team. Transmission of human immunodeficiency virus and hepatitis C virus from an organ donor to four transplant recipients. Am J Transplant. 2011;11:1218-25. https://doi.org/10.1111/j.1600-6143.2011.03597.x
European Directorate for the Quality of Medicines and Healthcare (EDQM). Guide to the quality and safety of organs, 8th Edition. Fecha de consulta: 1 de diciembre del 2022. Disponible en: https://freepub.edqm.eu/publications/PUBSD-88/detail
Jones JM, Kracalik I, Levi ME, Bowman JS 3rd, Berger JJ, Bixler D, et al. Assessing solid organ donors and monitoring transplant recipients for human immunodeficiency virus, hepatitis B virus, and hepatitis C virus infection - U.S. Public Health Service Guideline, 2020. MMWR Recomm Rep. 2020;69:1-16. https://doi.org/10.15585/mmwr.rr6904a1
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’. Human immunodeficiency virus (HIV). Transfus Med Hemother. 2016;43:203-22. https://doi.org/10.1159/000445852
Ho DD, Moudgil T, Alam M. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N Engl J Med. 1989;321:1621-5. https://doi.org/10.1056/NEJM198912143212401
Cumming PD, Wallace EL, Schorr JB, Dodd RY. Exposure of patients to human immunodeficiency virus through the transfusion of blood components that test antibodynegative. N Engl J Med. 1989;321:941-6. https://doi.org/10.1056/NEJM198910053211405
Busch MP, Eble BE, Khayam-Bashi H, Heilbron D, Murphy EL, Kwok S, et al. Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells. N Engl J Med. 1991;325:1-5. https://doi.org/10.1056/NEJM199107043250101
Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J. Estimating per-act HIV transmission risk: A systematic review. AIDS. 2014;28:1509-19. https://doi.org/10.1097/QAD.0000000000000298
Hilfenhaus JW, Gregersen JP, Mehdi S, Volk R. Inactivation of HIV-1 and HIV-2 by various manufacturing procedures for human plasma proteins. Cancer Detect Prev. 1990;14:369-75.
Borchi B, Ambu S, Bresci S, Zanazzi M, Salvadori M, Leoncini F. Case report: HIV infection from a kidney transplant. Transplant Proc. 2010;42:2267-9. https://doi.org/10.1016/j.transproceed.2010.05.026
Bellandi T, Albolino S, Tartaglia R, Filipponi F. Unintended transplantation of three organs from an HIV-positive donor: Report of the analysis of an adverse event in a regional health care service in Italy. Transplant Proc. 2010;42:2187-9. https://doi.org/10.1016/j.transproceed.2010.05.034
Centers for Disease Control and Prevention (CDC). HIV transmitted from a living organ donor--New York City, 2009. MMWR Morb Mortal Wkly Rep. 2011;60:297-301.
Li CM, Ho YR, Liu YC. Transmission of human immunodeficiency virus through bone transplantation: A case report. J Formos Med Assoc. 2001;100:350-1.
Furlini G, Re MC, Bandini G, Albertazzi L, La Placa M. Antibody response to human immunodeficiency virus after infected bone marrow transplant. Eur J Clin Microbiol Infect Dis. 1988;7:664-6. https://doi.org/10.1007/BF01964248
Anthuber M, Kemkes BM, Heiss MM, Schuetz A, Kugler C. HIV infection after heart transplantation: A case report. J Heart Lung Transplant. 1991;10:611-3.
Karcher HL. HIV transmitted by bone graft. BMJ. 1997;314:1300. https://doi.org/10.1136/bmj.314.7090.1297h
Ahn J, Cohen SM. Transmission of human immunodeficiency virus and hepatitis C virus through liver transplantation. Liver Transpl. 2008;14:1603-8. https://doi.org/10.1002/lt.21534
Mukhopadhyay P, Kumar V, Rathi M, Kohli HS, Jha V, Sakhuja V. Transmission of human immunodeficiency virus infection by renal transplantation. Indian J Nephrol. 2012;22:133-5. https://doi.org/10.4103/0971-4065.97135
Mitra CS. Human immunodeficiency virus infection in a renal transplant recipient. Indian J Nephrol. 2004;14:25-7.
Samuel D, Castaing D, Adam R, Saliba F, Chamaret S, Misset JL, et al. Fatal acute HIV infection with aplastic anaemia, transmitted by liver graft. Lancet. 1988;1:1221-2. https://doi.org/10.1016/s0140-6736(88)92033-8
Humar A, Morris M, Blumberg E, Freeman R, Preiksaitis J, Kiberd B, et al. Nucleic acid testing (NAT) of organ donors: Is the ‘best’ test the right test? A consensus conference report. Am J Transplant. 2010;10:889-99. https://doi.org/10.1111/j.1600-6143.2009.02992.x
Hans R, Marwaha N. Nucleic acid testing-benefits and constraints. Asian J Transfus Sci. 2014;8:2-3. https://doi.org/10.4103/0973-6247.126679
Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, et al. Screening for HIV Infection: US Preventive Services Task Force Recommendation Statement. JAMA. 2019;321:2326-36. https://doi.org/10.1001/jama.2019.6587
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