Epidemiology and healthcare resource utilization in atopic dermatitis in Colombia: A retrospective analysis of data from the National Health Registry from 2015 to 2020
Abstract
Introduction: Atopic dermatitis, also known as eczema or atopic eczema, is a chronic inflammatory skin disorder characterized by the presence of pruritus accompanied by itching. In Colombia, epidemiological and healthcare resource utilization information regarding this pathology is limited.
Objective: To describe atopic dermatitis epidemiological characteristics and healthcare resource utilization patterns in Colombia.
Material and methods: A retrospective database study using real-world data obtained from the national claims database SISPRO (Sistema de Información para la Protección Social) for the 2015-2020 period was carried out. Sociodemographic (age, and health services delivery), epidemiological (incidence, prevalence, and comorbidities), and healthcare resource utilization data were extracted from the SISPRO database.
Results: The epidemiological results showed increased incidence and prevalence of atopic dermatitis in Colombia in the 2018-2019 period compared to 2015-2017. Accordingly, the number of medical consultations (particularly with specialists), the number of procedures, and the number of hospitalizations of patients with atopic dermatitis increased. Topic and systemic corticoids were the most frequently prescribed drugs.
Conclusions: Diagnoses of atopic dermatitis in Colombia increased with a concomitant increase in healthcare resource utilization during 2015-2020, which was possibly slowed down by the arrival of the Covid-19. This study may help physicians gaining a better understanding of the disease, improving atopic dermatitis patient management.
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References
Leung DYM, Eichenfield LF, Boguniewicz M. Atopic dermatitis (Atopic eczema). In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K (editors). Fitzpatrick’s Dermatology in General Medicine, 8th edition. New York, NY: The McGraw-Hill Companies; 2012.
Avena-Woods C. Overview of atopic dermatitis. Am J Manag Care. 2017;23:S115-23. https://doi.org/10.5415/apallergy.2013.3.2.79
Boothe WD, Tarbox JA, Tarbox MB. Atopic dermatitis: Pathophysiology. Adv Exp Med Biol. 2017;1027:21-37. https://doi.org/10.1007/978-3-319-64804-0_3
Williams H, Robertson C, Stewart A, Aït-Khaled N, Anabwani G, Anderson R, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. J Allergy Clin Immunol. 1999;103:125-38. https://doi.org/10.1016/s0091-6749(99)70536-1
Barbarot S, Auziere S, Gadkari A, Girolomoni G, Puig L, Simpson EL et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 2018;73:1284-93. https://doi.org/10.1111/all.13401
Kim JP, Chao LX, Simpson EL, Silverberg JI. Persistence of atopic dermatitis (AD): A systematic review and meta-analysis. J Am Acad Dermatol. 2016;75:681-7.e11. https://doi.org/10.1016/j.jaad.2016.05.028
Nutten S. Atopic dermatitis: Global epidemiology and risk factors. Ann Nutr Metab. 2015;66(Suppl.1):8-16. https://doi.org/10.1159/000370220
Chiesa Fuxench ZC, Block JK, Boguniewicz M, Boyle J, Fonacier L, Gelfand JM, et al. Atopic dermatitis in America Study: A cross-sectional study examining the prevalence and disease burden of atopic dermatitis in the US adult population. J Invest Dermatol. 2019;139:583-90. https://doi.org/10.1016/j.jid.2018.08.028
Kaaz K, Szepietowski JC, Matusiak Ł. Influence of itch and pain on sleep quality in atopic dermatitis and psoriasis. Acta Derm Venereol. 2019;99:175-80. https://doi.org/10.2340/00015555-3065
Li JC, Fishbein A, Singam V, Patel KR, Zee PC, Attarian H, et al. Sleep disturbance and sleep-related impairment in adults with atopic dermatitis: A cross-sectional study. Dermatitis. 2018;29:270-7. https://doi.org/10.1097/DER.0000000000000401
Peters N, Peters AT. Atopic dermatitis. Allergy Asthma Proc. 2019;40:433-6. https://doi.org/10.2500/aap.2019.40.4265
Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387:1109-22. https://doi.org/10.1016/S0140-6736(15)00149-X
Chong M, Fonacier L. Treatment of eczema: Corticosteroids and beyond. Clin Rev Allergy Immunol. 2016;51:249-62. https://doi.org/10.1007/s12016-015-8486-7
Werfel T, Claes C, Kulp W, Greiner W, von der Schulenburg J-M. Therapy of atopic eczema. GMS Health Technol Assess. 2006;2:Doc19.
Kramer ON, Strom MA, Ladizinski B, Lio PA. The history of atopic dermatitis. Clin Dermatol. 2017;35:344-8. https://doi.org/10.1016/j.clindermatol.2017.03.005
Das A, Panda S. Use of topical corticosteroids in dermatology: An evidence-based approach. Indian J Dermatol. 2017;62:237-50. https://doi.org/10.4103/ijd.IJD_169_17
Denby KS, Beck LA. Update on systemic therapies for atopic dermatitis. Curr Opin Allergy Clin Immunol. 2012;12:421-6. https://doi.org/10.1097/ACI.0b013e3283551da5
Roekevisch E, Spuls PI, Kuester D, Limpens J, Schmitt J. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systematic review. J Allergy Clin Immunol. 2014;133:429-38. https://doi.org/10.1016/j.jaci.2013.07.049
Megna M, Napolitano M, Patruno C, Villani A, Balato A, Monfrecola G, et al. Systemic treatment of adult atopic dermatitis: A review. Dermatol Ther (Heidelb). 2017;7:1-23. https://doi.org/10.1007/s13555-016-0170-1
U.S. Food and Drug Administration. FDA approves. Accessed: December 10, 2021. Available at: https://www.fda.gov/news-events/press-announcements/fda-approves-neweczema-drug-dupixent
Zhou S, Qi F, Gong Y, Zhang J, Zhu B. Biological therapies for atopic dermatitis: A systematic review. Dermatology. 2021;237:542-52. https://doi.org/10.1159/000514535
Ratchataswan T, Banzon TM, Thyssen JP, Weidinger S, Guttman-Yassky E, Phipatanakul W. Biologics for treatment of atopic dermatitis: Current status and future prospect. J Allergy Clin Immunol Pract. 2021;9:1053-65. https://doi.org/10.1016/j.jaip.2020.11.034
Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SM, et al. The global burden of atopic dermatitis: Lessons from the Global Burden of Disease Study 1990-2017. Br J Dermatol. 2021;184:304-9. https://doi.org/10.1111/bjd.19580
Silverberg JI. Public health burden and epidemiology of atopic dermatitis. Dermatol Clin. 2017;35:283-9. https://doi.org/10.1016/j.det.2017.02.002
Drucker AM, Qureshi AA, Amand C, Villeneuve S, Gadkari A, Chao J, et al. Health care resource utilization and costs among adults with atopic dermatitis in the United States: A claims-based analysis. J Allergy Clin Immunol Pract. 2018;6:1342-8. https://doi.org/10.1016/j.jaip.2017.10.024
Igarashi A, Fujita H, Arima K, Inoue T, Dorey J, Fukushima A et al. Health-care resource use and current treatment of adult atopic dermatitis patients in Japan: A retrospective claims database analysis. J Dermatol. 2019;46:652-61. https://doi.org/10.1111/1346-8138.14947
Sánchez J, Sánchez A, Cardona R. Particular characteristics of atopic eczema in tropical environments. The Tropical Environment Control for Chronic Eczema and Molecular Assessment (TECCEMA) cohort study. An Bras Dermatol. 2017;92:177-83. https://doi.org/10.1590/abd1806-4841.20175140
Dennis RJ, Caraballo L, García E, Rojas MX, Rondóon MA, Pérez A, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: A cross-sectional study. BMC Pulm Med. 2012;12:17. https://doi.org/10.1186/1471-2466-12-17
Departamento Administrativo Nacional de Estadística. Proyecciones de población. Accessed: December 10, 2021. Available at: https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/proyecciones-de-poblacion
Yew YW, Thyssen JP, Silverberg JI. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol. 2019;80:390-401. https://doi.org/10.1016/j.jaad.2018.09.035
Williams H, Stewart A, von Mutius E, Cookson W, Anderson HR. Is eczema really on the increase worldwide? J Allergy Clin Immunol. 2008;121:947-54.e15. https://doi.org/10.1016/j.jaci.2007.11.004
Cortés A, Mendoza L, Cañón- Betancourt A, Vivas-Martínez J, Díaz-Ortega M, Pinzón-Flórez E. Guía de práctica clínica (GPC) para el diagnóstico y tratamiento de la dermatitis atópica en Colombia. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 2020. Accessed: December 13, 2021. Available at: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1508
Singh P, Silverberg J. Real-world outpatient prescription patterns for atopic dermatitis in the United States. Dermatitis. 2019;30:294-9. https://doi.org/10.1097/DER.0000000000000520
Alexander T, Maxim E, Cardwell LA, Chawla A, Feldman SR. Prescriptions for atopic dermatitis: Oral corticosteroids remain commonplace. J Dermatolog Treat. 2018;29:238-40. https://doi.org/10.1080/09546634.2017.1365112
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