Neuropsychological and physical development of patients diagnosed with congenital hypothyroidism at the San Ignacio University Hospital between 2001 and 2017
Abstract
Introduction: Congenital hypothyroidism is the leading cause of preventable cognitive disability in the world. Therefore, screening programs have been developed in order to reduce the neurological sequelae associated with this pathology.
Objective: To describe the demographic characteristics, the treatment, and the follow-up of patients diagnosed with congenital hypothyroidism in the screening program at the San Ignacio University Hospital in Bogotá, Colombia.
Materials and methods: We conducted an observational cross-sectional study. The study population was patients diagnosed with congenital hypothyroidism at the Hospital between 2001 and 2017.
Results: Fourteen of the 19 patients diagnosed with congenital hypothyroidism in the hospital screening program were contacted. All of the patients had schooling, most of them had adequate weight and height, and two had short stature. In most of them, the etiological diagnosis was thyroid hypoplasia, and all began the treatment and follow-up in an adequate way. The most frequent alteration in the neuropsychological tests was in the memory domain and the level of maternal education could be related to an abnormal result in the domain of language.
Conclusion: In our study, alterations in the memory tests were the most prevalent; however, due to the design and type of study, more research is required to establish associations. A low frequency of abnormal growth and puberty was found.
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References
Bernal J, Guadaño-Ferraz A, Morte B. Perspectives in the study of thyroid hormone action on brain development and function. Thyroid. 2003;13:1005-12. https://doi.org/10.1089/105072503770867174
Dalili S, Rezvani SM, Dalili H, Mohtasham-Amiri Z, Mohammadi H, Abrisham-Kesh S, et al. Congenital hypothyroidism: Etiology and growth-development outcome. Acta Med Iran. 2014;52:752-6.
Tillotson SL, Fuggle PW, Smith I, Ades AE, Grant DB. Relation between biochemical severity and intelligence in early treated congenital hypothyroidism: A threshold effect. BMJ. 1994;309:440-5. https://doi.org/10.1136/bmj.309.6952.440
García-Morales L, Rodríguez-Arnao MD, Rodríguez-Sánchez A, Dulín-Íñiguez E, Álvarez-González MA. Sustained attention in school-age children with congenital hypothyroidism: Influence of episodes of overtreatment in the first three years of life. Neurologia (Engl ed). 2020;35:226-32. https://doi.org/10.1016/j.nrl.2017.08.003
Khammarnia M, Siakhulak FR, Ansari H, Peyvand M. Risk factors associated with congenital hypothyroidism: A case-control study in Southeast Iran. Electron Physician. 2018;10:6286-91. https://doi.org/10.19082/6286
Peñaloza L, Forero C, Céspedes C. Caracterización de pacientes con hipotiroidismo congénito en el Hospital Universitario San Ignacio entre 2001 y 2017. Biomédica. 2020;40:528-33. https://doi.org/10.7705/biomedica.5334
Jones JH, Gellén B, Paterson WF, Beaton S, Donaldson MD. Effect of high versus low initial doses of L-thyroxine for congenital hypothyroidism on thyroid function and somatic growth. Arch Dis Child. 2008;93:940-4. https://doi.org/10.1136/adc.2007.120618
Rahmani K, Yarahmadi S, Etemad K, Koosha A, Mehrabi Y, Aghang N, et al. Congenital hypothyroidism: Optimal initial dosage and time of initiation of treatment: A systematic review. Int J Endocrinol Metab. 2016;14:e36080. https://doi.org/10.5812/ijem.36080
Núñez A, Bedregal P, Becerra C, Grob L F. Neurodevelopmental assessment of patients with congenital hypothyroidism. Rev Med Chil. 2017;145:1579-87. https://doi.org/10.4067/s0034-98872017001201579
Komur M, Ozen S, Okuyaz C, Makharoblıdze K, Erdogan S. Neurodevelopment evaluation in children with congenital hypothyroidism by Bayley-III. Brain Dev. 2013;35:392-7. https://doi.org/10.1016/j.braindev.2012.07.003
Baysal BT, Baysal B, Genel F, Erdur B, Ozbek E, Demir K, et al. Neurodevelopmental outcome of children with congenital hypothyroidism diagnosed in a national screening program in Turkey. Indian Pediatr. 2017;54:381-4. https://doi.org/10.1007/s13312-017-1111-5
van Trotsenburg P, Stoupa A, Léger J, Rohrer T, Peters C, Fugazzola L, et al. Congenital hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology. Thyroid. 2021;31:387-419. https://doi.org/10.1089/thy.2020.0333
Lamônica DAC, Anastácio-Pessan FDL, Ferraz PMDP, Ribeiro CDC. Performance in motor, communicative and cognitive skills of girls with congenital hypothyroidism treated from the neonatal period. Codas. 2020;32:e20190017. https://doi.org/10.1590/2317-1782/20192019017
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