Severe disseminated acute toxoplasmosis in an adult immunocompetent patient from the Colombian Pacific
Abstract
We present the case of a 72-year-old immunocompetent patient from Chocó, Colombia, with a 12-day course of fever, headache, progressive neurological deterioration, and rapid evolution to multiorgan failure and death.
In the histopathological study of tissues obtained at necropsy, tissue cysts morphologically suggestive of being bradyzoites of Toxoplasma gondii were identified and confirmed by immunohistochemistry in heart, brain, and striated muscle.
Downloads
References
Sobanski V, Ajzenberg D, Delhaes L, Bautin N, Just N. Severe toxoplasmosis in immunocompetent hosts: Be aware of atypical strains. Am J Respir Crit Care Med. 2013;
:1143-5. https://doi.org/10.1164/rccm.201209-1635LE
Carme B, Bissuel F, Ajzenberg D, Bouyne R, Aznar C, Demar M, et al. Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana. J Clin Microbiol. 2002;40:4037-44. https://doi.org/10.1128/JCM.40.11.4037-4044.2002
Montoya J, Liesenfeld O. Toxoplasmosis. Lancet. 2004;363:1965-76. https://doi.org/10.1016/S0140-6736(04)16412-X
Saadatnia G, Golkar M. A review on human toxoplasmosis. Scand J Infect Dis. 2012;44:805-14. https://doi.org/10.3109/00365548.2012.693197
Nunura J, Endo S, Salazar D, Rodríguez A, Pereyra S, Solís H, et al. Disseminated toxoplasmosis in an immunocompetent patient from Peruvian Amazon. Rev Inst Med Trop Sao Paulo. 2010;52:107-10. https://doi.org/10.1590/S0036-46652010000200008
Montoya J. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis. 2002;185(Suppl.1):S73-82. https://doi.org/10.1086/338827
Petersen E, Ajzenberg D, Mandelbrot L, Gómez-Marín JE. Protozoan diseases: Toxoplasmosis. International Encyclopedia of Public Health. Second edition. Elsevier; 2017. p.114-32. https://doi.org/10.1016/B978-0-12-803678-5.00361-1
Demar M, Ajzenberg D, Maubon D, Djossou F, Panchoe D, Punwasi W, et al. Fatal outbreak of human toxoplasmosis along the Maroni River: Epidemiological, clinical, and parasitological aspects. Clin Infect Dis. 2007;45:88-95. https://doi.org/10.1086/521246
Leal F, Cavazzana C, Franco De Andrade H, Galisteo AJ Jr, de Mendonça JS, Kallas EG. Toxoplasma gondii pneumonia in immunocompetent subjects: Case report and review. Clin Infect Dis. 2007;44:e62-6. https://doi.org/10.1086/511871
Demar M, Hommel D, Djossou F, Peneau C, Boukhari R, Louvel D, et al. Acute toxoplasmoses in immunocompetent patients hospitalized in an intensive care unit in French Guiana. Clin Microbiol Infect. 2012;18:E221-31. https://doi.org/10.1111/j.1469-0691.2011.03648.x
Pena HF, Gennari SM, Dubey JP, Su C. Population structure and mouse-virulence of Toxoplasma gondii in Brazil. Int J Parasitol. 2008;38:561-9. https://doi.org/10.1016/j.ijpara.2007.09.004
De la Torre A, Sauer A, Bourcier T, Speeg-Schatz C, Ballonzoli L, Ajzenberg D, et al. Severe South American ocular toxoplasmosis is associated with decreased IFNgamma/IL-17A and increased IL-6/IL-13 intraocular levels. PLoS Neglected Trop Dis. 2013;7:e2541. https://doi.org/10.1371/journal.pntd.0002541
Pino L, Salinas J, López M. Description of an epidemic outbreak of acute toxoplasmosis in immunocompetent patients from Colombian Armed Forces during jungle operations. Infectio. 2009;13:83-91. https://doi.org/10.1016/S0123-9392(09)70729-5
Zea F. Inmunocompentencia en adultos: más que VIH negativo. Colombia Médica. 2016;47:176.
Darde ML. Toxoplasma gondii, “new” genotypes and virulence. Parasite. 2008;15:366-71. https://doi.org/10.1051/parasite/2008153366
Some similar items:
- Sebastián Posada-Bustos, Ana Cristina Mariño , Eugenia Espinosa-García , Clinical outcomes of pediatric patients with congenital toxoplasmosis in a fourthlevel center Introduction. Congenital , Biomedica: Vol. 44 No. 4 (2024)
- Angélica María Ramírez, Yesmit Karina Ríos, Néstor Fabián Galvis, Elsie Entrena, Nidia Victoria Mariño, Diana Marcela Rangel, María Alejandra Araque, Darlis Mayerlis Cabarique, Mateo Murillo , Jorge Enrique Gómez-Marín, Seroprevalence and molecular detection of Toxoplasma gondii among donors in a blood bank in Cúcuta, Colombia Introduction: Toxoplasma gondii infection , Biomedica: Vol. 39 No. Supl. 2 (2019): Enfermedades transmisibles en el trópico, agosto
- Elizabeth Borrero, Gabriel Carrasquilla, Neal Alexander, Decentralization and health system reform: What is their impact on malaria incidence in Colombian municipalities? , Biomedica: Vol. 32 (2012): Suplemento 1, Malaria
- Rubén Santiago Nicholls, Zulma Milena Cucunubá, Angélica Knudson, Astrid Carolina Flórez, Marleny Montilla, Concepción Judith Puerta, Paula Ximena Pavía, Acute Chagas disease in Colombia: a rarely suspected disease. Report of 10 cases presented during the 2002-2005 period , Biomedica: Vol. 27 No. 1esp (2007): Enfermedad de Chagas
- Sandra Lorena Girón, Julio César Mateus, Fabián Méndez, Impact of an open waste disposal site on the occurrence of respiratory symptoms and on health care costs of children , Biomedica: Vol. 29 No. 3 (2009)
- José Joaquín Carvajal, Ligia Inés Moncada, Mauricio Humberto Rodríguez, Ligia del Pilar Pérez, Víctor Alberto Olano, Characterization of Aedes albopictus (Skuse, 1894) (Diptera:Culicidae) larval habitats near the Amazon River in Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Jorge Iván Zapata-Valencia, Diana Maritza Jurado-Orejuela, Ofelia Flórez-Echeverry, Erica Marcela Aristizábal-Giraldo, Jhonathan León Gallego-Franco, María Camila Yolanda Ramírez-Uribe, Jemina Rentería-Molina, Alejandra Sandoval-Villareal, Yermaín Ulabarri-Valencia, Juan Carlos Zambrano-Camelo, Prevalence of intestinal parasites in street dwellers attending a shelter in Cali, Colombia , Biomedica: Vol. 44 No. 4 (2024)
- Patricia Escobar, Katherine Paola Luna, Indira Paola Hernández, César Mauricio Rueda, María Magdalena Zorro, Simon L. Croft, In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole , Biomedica: Vol. 29 No. 3 (2009)
- Gustavo Pradilla, Julio César Mantilla, Reynaldo Badillo, Human rabies encephalitis by a vampire bat bite in an urban area of Colombia , Biomedica: Vol. 29 No. 2 (2009)
- Rosa Magdalena Uscátegui, Adriana M. Correa, Jaime Carmona-Fonseca, Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria , Biomedica: Vol. 29 No. 2 (2009)

Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |