Prescribing patterns of antiparkinson drugs in a group of Colombian patients, 2015
Abstract
Introduction: Parkinson’s disease, whose prevalence in Colombia is 4.7 per 1,000 inhabitants, is a public health problem and a therapeutic challenge for health professionals.
Objective: To determine the prescribing patterns of antiparkinson drugs and the variables associated with its use in a population from Colombia.
Materials and methods: We conducted a descriptive cross-sectional study. We selected patients who had been given antiparkinson drugs uninterruptedly between January 1st and March 31st, 2015 from a systematized database of approximately 3.5 million people affiliated to the Colombian health system. We included sociodemographic, pharmacologic and comedication variables. For the multivariate analysis, we used the IBM SPSS™-22 software.
Results: A total of 2,898 patients was included; the mean age was 65.1years, and 50.7% were men; 69.4% (n=2010) of people received monotherapy and 30.6% combination therapy with two to five antiparkinson drugs. The most frequently prescribed drugs were: levodopa 45.5% (n=1,318 patients), biperiden 23.1% (670), amantadine 18.3% (531) and pramipexole 16.3% (471). The most commonly used association was levodopa/carbidopa + entacapone (n=311; 10.7%). Multivariate analysis showed that being male (OR=1.56; 95%CI: 1.321-1.837), over 60 years (OR=1.41; 95%CI 1.112-1.782) and receiving treatment in the city of Barranquilla (OR=2.23; 95%CI 1.675-2.975) were statistically associated with a greater risk of using combination therapy; 68.2% (n=1,977) patients were given concomitant treatment with other drugs.
Conclusions: Prescribing habits of drugs with high therapeutic value predominated, mainly in antiparkinson drugs monotherapy. Most were employed in the usual recommended doses. It is necessary to explore the clinical effectiveness of the medications studied and differentiate between disease and parkinsonian syndromes subtypes.
Downloads
References
Alves G, Forsaa EB, Pedersen KF, DreetzGjerstad M, Larsen JP. Epidemiology of Parkinson’s disease. J Neurol. 2008;255:18-32. https://doi.org/10.1007/s00415-008-5004-3
World Health Organization. Neurological Disorders: Public Health Challenges. Chapter 3: Neurological disorders: A public health approach. Geneva: WHO; 2006. p. 140-8.
Nutt JG, Wooten GF. Clinical practice. Diagnosis and initial management of Parkinson’s disease. N Engl J Med. 2005;353:1021-7. https://doi.org/10.1056/NEJMcp043908
Jankovic J, Poewe W. Therapies in Parkinson’s disease. Curr Opin Neurol. 2012;25:433-47. https://doi.org/10.1097/WCO.0b013e3283542fc2
Grupo de Trastornos del Movimiento de la Asociación Colombiana de Neurología. Generalidades de la enfermedad de Parkinson. Acta Neurol Colomb. 2014;30:2-7.
Findley LJ. The economic impact of Parkinson’s disease. Parkinsonism Relat Disord. 2007;13:S8-S12. https://doi.org/10.1016/j.parkreldis.2007.06.003
Takeuchi Y, Guevara JG. Prevalencia de las enfermedades neurológicas en el Valle del Cauca. Estudio Neuroepidemiológico Nacional (EPINEURO). Colomb Med. 1999;30:74-81.
Pradilla AG, Vesga A BE, León-Sarmiento FE, Grupo GENECO. National neuroepidemiological study in Colombia (EPINEURO). Rev Panam Salud Pública. 2003;14:104-11.
Sánchez JL, Buriticá O, Pineda D, Uribe CS, Palacio LG. Prevalence of Parkinson’s disease and parkinsonism in a Colombian population using the capture-recapture method. Int J Neurosci. 2004;114:175-82. https://doi.org/10.1080/00207450490269444
Diazgranados JA, Chan L, Gómez LF, Lozano AF, Ramírez M. Descripción de la población de pacientes con enfermedad de Parkinson en un centro médico neurológico en la ciudad de Cali, Colombia. Acta Neurol Colomb. 2011;27:205-10.
Gaida R, Truter I. Prescribing patterns for Parkinson’s disease in a South African patient population. J App Pharm Sci. 2014;4:29-34. https://doi.org/10.7324/JAPS.2014.40307
Leoni O, Martignoni E, Cosentino M, Michielotto D, Calandrella D, Zangaglia R, et al. Drug prescribing patterns in Parkinson’s disease: A pharmacoepidemiological survey in a cohort of ambulatory patients. Pharmacoepidemiol Drug Saf. 2002;11:149-57. https://doi.org/10.1002/pds.682
Nakaoka S, Ishizaki T, Urushihara H, Satoh T, Ikeda S, Yamamoto M, et al. Prescribing pattern of anti-Parkinson drugs in Japan: A trend analysis from 2005 to 2010. PloS One. 2014;9:e99021. https://doi.org/10.1371/journal.pone.0099021
Ministerio de Salud y Protección Social. Resolución No. 5926 de 23 de diciembre de 2014. Cited: October 5, 2015. Available in: https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%C3%B3n%205926%20de%202014.pdf
Connolly BS, Lang AE. Pharmacological treatment of Parkinson disease: A review. JAMA. 2014;311:1670-83. https://doi.org/10.1001/jama.2014.3654
Trifirò G, Savica R, Morgante L, Vanacore N, Tari M, Moretti S, et al. Prescribing pattern of anti-Parkinson drugs in Southern Italy: Cross-sectional analysis in the years 2003-2005. Parkinsonism Relat Disord. 2008;14:420-5. https://doi.org/10.1016/j.parkreldis.2007.10.010
Tan EK, Yeo AP, Tan V, Pavanni R, Wong MC. Prescribing pattern in Parkinson’s disease: Are cost and efficacy overriding factors? Int J Clin Pract. 2005;59:511-4. https://doi.org/10.1111/j.1368-5031.2005.00426.x
Gjerden P, Slordal L, Bramness JG. The use of antipsychotic and anticholinergic antiparkinson drugs in Norway after the withdrawal of orphenadrine. Br J Clin Pharmacol. 2009;68:238-42. https://doi.org/10.1111/j.1365-2125.2009.03446.x
Althaus A, Becker OA, Spottke A, Dengler R, Schneider F, Kloss M, et al. Frequency and treatment of depressive symptoms in a Parkinson’s disease registry. Parkinsonism Relat Disord. 2008;14:626-32. https://doi.org/10.1016/j.parkreldis.2008.01.016
Mostile G, Jankovic J. Treatment of dysautonomia associated with Parkinson’s disease. Parkinsonism Relat Disord. 2009;15(Suppl.3):S224-32. https://doi.org/10.1016/S1353-8020(09)70820-X
Seppi K, Weintraub D, Coelho M, Pérez-Lloret S, Fox SH, Katzenschlager R, et al. The movement disorder society evidence-based medicine review update: Treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord. 2011;26(Suppl.3):S42-80. https://doi.org/10.1002/mds.23884
Abasolo-Osinaga E, Abecia-Inchaurregui LC, Fernández-Díaz E, Barcenilla-Laguna A, Bañares-Onraita T. The prevalence and pharmacological cost of Parkinson’s disease in Spain. Rev Neurol. 2006;43:641-5.
Machado-Alba JE, Morales-Plaza CD. Patrones de prescripción de antipsicóticos en pacientes afiliados al Sistema General de Seguridad Social en Salud de Colombia. Biomédica. 2013;33:418-28. https://doi.org/10.1016/10.7705/biomedica.v33i3.1529
Machado-Alba JE, Giraldo-Giraldo C, Machado-Duque ME. Quality of conventional release verapamil prescription in patients with arterial hypertension. Rev Calid Asist. 2015;30:72-8. https://doi.org/10.1016/j.cali.2015.01.009
Some similar items:
- Elizabeth Borrero, Gabriel Carrasquilla, Neal Alexander, Decentralization and health system reform: What is their impact on malaria incidence in Colombian municipalities? , Biomedica: Vol. 32 (2012): Suplemento 1, Malaria
- Raúl Murillo, Ricardo Cendales, Carolina Wiesner, Marion Piñeros, Sandra Tovar, Effectiveness of cytology-based cervical cancer screening in the Colombian health system , Biomedica: Vol. 29 No. 3 (2009)
- Sandra Lorena Girón, Julio César Mateus, Fabián Méndez, Impact of an open waste disposal site on the occurrence of respiratory symptoms and on health care costs of children , Biomedica: Vol. 29 No. 3 (2009)
- José Joaquín Carvajal, Ligia Inés Moncada, Mauricio Humberto Rodríguez, Ligia del Pilar Pérez, Víctor Alberto Olano, Characterization of Aedes albopictus (Skuse, 1894) (Diptera:Culicidae) larval habitats near the Amazon River in Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Andrés Páez, Gloria Rey, Carlos Agudelo, Alvaro Dulce, Edgar Parra, Hernando Díaz-Granados, Damaris Heredia, Luis Polo, Outbreak of urban rabies transmitted by dogs in Santa Marta, northern Colombia , Biomedica: Vol. 29 No. 3 (2009)
- Patricia Escobar, Katherine Paola Luna, Indira Paola Hernández, César Mauricio Rueda, María Magdalena Zorro, Simon L. Croft, In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole , Biomedica: Vol. 29 No. 3 (2009)
- Gustavo Pradilla, Julio César Mantilla, Reynaldo Badillo, Human rabies encephalitis by a vampire bat bite in an urban area of Colombia , Biomedica: Vol. 29 No. 2 (2009)
- Mauricio Beltrán, María Cristina Navas, María Patricia Arbeláez, Jorge Donado, Sergio Jaramillo, Fernando De la Hoz, Cecilia Estrada, Lucía del Pilar Cortés, Amalia de Maldonado, Gloria Rey, Seroprevalence of hepatitis B virus and human immunodeficiency virus infection in a population of multiply-transfused patients in Colombia , Biomedica: Vol. 29 No. 2 (2009)
- Rosa Magdalena Uscátegui, Adriana M. Correa, Jaime Carmona-Fonseca, Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria , Biomedica: Vol. 29 No. 2 (2009)
- Claudia M.E. Romero-Vivas, Luis Eduardo Castro, Lila Visbal, Ana María Santos, Esther Díaz, Cutaneous myiasis by Cochliomyia hominivorax (Coquerel) (Díptera Calliphoridae) in Hospital Universidad del Norte, Soledad, Atlántico , Biomedica: Vol. 29 No. 1 (2009)
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
