Three cases of de novo multiple myeloma after kidney transplantation
Abstract
Light chain-associated kidney compromise is frequent in patients with monoclonal gammopathies; it affects the glomeruli or the tubules, and its most common cause is multiple myeloma. It may develop after a kidney transplant due to recurrence of a preexisting multiple myeloma or it can be a de novo disease manifesting as graft dysfunction and proteinuria. A kidney biopsy is always necessary to confirm the diagnosis.
We describe three cases of kidney graft dysfunction due to multiple myeloma in patients without presence of the disease before the transplant.
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References
Colvin R, Chang A. Diagnostic pathology. Kidney diseases. First edition. Salt Lake City: Amirsys; 2011. p. 244-8.
Wirk B. Renal failure in multiple myeloma: A medical emergency. Bone Marrow Transplant. 2011;46:771-83. http://dx.doi.org/10.1038/bmt.2011.8
Spitzer TR, Sykes M, Tolkoff-Rubin N, Kawai T, McAfee SL, Dey BR, et al. Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation. 2011;91:672-6. http://dx.doi.org/10.1097/TP.0b013e31820a3068
Geiger X, Harris D, van Buren D, Goral S, Helderman JH, Fogo A. A middle-aged woman with refractory graft dysfunction in the early posttransplant period. Am J Kidney Dis. 1999;33:998-1003. http://dx.doi.org/10.1016/S0272-6386(99)70441-5
Balamuthusamy S, Hamrahian M, Zhang R, Batuman V. Myeloma kidney with isolated tubulointerstitial light chain deposition in a renal allograft. Clin Transplant. 2009;23:848-52. http://dx.doi.org/10.1111/j.1399-0012.2009.00967.x
Foster K, Cohen DJ, D’Agati VD, Markowitz GS. Primary renal allograft dysfunction. Am J Kidney Dis. 2004;44:376-81. http://dx.doi.org/10.1053/j.ajkd.2003.10.047
Kapoulas S, Raptis V, Papaioannou M. New aspects on the pathogenesis of renal disorders related to monoclonal gammopathies. Nephrol Ther. 2015;11:135-43. http://dx.doi.org/10.1016/j.nephro.2014.12.005
Goel SK, Granger D, Bellovich K, Marin M, Qu H, El-Ghoroury M. Myeloma cast nephropathy: A rare cause of primary renal allograft dysfunction. Transplant Proc. 2011;43:2784-8. http://dx.doi.org/10.1016/j.transproceed. 2011.06.058
Savenkoff B, Aubertin P, Ladriere M, Hulin C, Champigneulle J, Frimat L. A de novo monoclonal immuno-globulin deposition disease in a kidney transplant recipient: A case report. J Med Case Rep. 2014;8:205. http://dx.doi.org/10.1186/1752-1947-8-205
Perkowska-Ptasinska A, Glyda M, Paczkowski M, Durlik M. Primary kidney allograft dysfunction due to myeloma-cast nephropathy: A case report. Transplant Proc. 2007;39:1683-4. http://dx.doi.org/10.1016/j.transproceed.2007.01.089
Tanenbaum ND, Howell DN, Middleton JP, Spurney RF. Lambda light chain deposition disease in a renal allograft. Transplant Proc. 2005;37:4289-92. http://dx.doi.org/10.1016/j.transproceed.2005.10.030
Moiz A, Javed T, Garcés J, Staffeld-coit C, Paueksakon P. Late recurrence of light chain deposition disease after kidney transplantation treated with bortezomib: A case report. Ochsner J. 2014;14:445-9.
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