Successful treatment of hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation secondary to histoplasmosis in a patient with HIV/AIDS
Abstract
Haemophagocytic lymphohistiocytosis is an uncommon syndrome that results from an uncontrolled activation of macrophages and lymphocytes resulting in the compromise of multiple organs that is potentially fatal without timely treatment. It can be hereditary or a secondary result of infectious processes, neoplasms or autoimmune conditions. We present the case of a patient with HIV/AIDS who developed hemophagocytic lymphohistiocytosis as well as disseminated intravascular coagulation associated with histoplasmosis and who was successfully treated with amphotericin B, steroids and transitory dialytic support.
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References
Janka GE, Lehmberg K. Hemophagocytic syndromes - An update. Blood Rev. 2014;28:135-42. http://dx.doi.org/10.1016/j.blre.2014.03.002.
Rouphael NG, Talati NJ, Vaughan C, Cunningham K, Moreira R, Gould C. Infections associated with haemophagocytic syndrome. Lancet Infect Dis. 2007;7:814-22. http://dx.doi.org/10.1016/S1473-3099(07)70290-6.
Larroche C. Hemophagocytic lymphohistiocytosis in adults: Diagnosis and treatment. Jt Bone Spine. 2012;79:356-61. http://dx.doi.org/10.1016/j.jbspin.2011.10.015.
Li J, Wang Q, Zheng W, Ma J, Zhang W, Wang W, et al. Hemophagocytic lymphohistiocytosis: Clinical analysis of 103 adult patients. Medicine (Baltimore). 2014;93:100-5. http://dx.doi.org/10.1097/MD.0000000000000022.
Foundation KDIGO. Clinical Guidelines. National Kidney. Section 2: AKI Definition. Kidney Int Suppl. 2012;2:19-36.
Henter J, Horne A, Aricó M, Egeler R, Filipovich A, Imashuku S, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124-31. http://dx.doi.org/10.1002/pbc.21039.
Allen CE, Yu X, Kozinetz CA, McClain KL. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008;50:1227-35. http://dx.doi.org/10.1002/pbc.21423.
Doyle T, Bhagani S, Cwynarski K. Haemophagocytic syndrome and HIV. Curr Opin Infect Dis. 2009;22:1-6. http://dx.doi.org/10.1097/QCO.0b013e32832180b0.
Fardet L, Lambotte O, Meynard J-L, Kamouh W, Galicier L, Marzac C, et al. Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: Clinical features, underlying diseases and prognosis. AIDS. 2010;24:1299-306. http://dx.doi.org/10.1097/QAD.0b013e328339e55b.
Subedee A, van Sickels N. Hemophagocytic syndrome in the setting of AIDS and disseminated histoplasmosis: Case report and a review of literature. J Int Assoc Provid AIDS Care. 2015;1-7. http://dx.doi.org/10.1177/2325957415570740.
Nieto-Ríos JF, Aristizábal-Alzate A, Ocampo C, Serrano-Gayubo AK, Serna-Higuita LM, Zuluaga-Valencia G. Disseminated histoplasmosis and haemophagocytic syndrome in two kidney transplant patients. Nefrologia. 2012;32:683-4. http://dx.doi.org/10.3265/Nefrologia.pre2012.Jun.11508.
Lo MM, Mo JQ, Dixon BP, Czech KA. Disseminated histoplasmosis associated with hemophagocytic lympho-histiocytosis in kidney transplant recipients. Am J Transplant. 2010;10:687-91. http://dx.doi.org/10.1111/j.1600-6143.2009.02969.x.
Mehta R, Smith R. Hemophagocytic lymphohistiocytosis (HLH): A review of literature. Med Oncol. 2013;30:740. http://dx.doi.org/10.1007/s12032-013-0740-3.
Zhang L, Zhou J, Sokol L. Hereditary and acquired hemophagocytic lymphohistiocytosis. Cancer Control. 2014; 21:301-12.
Kaito K, Kobayashi M, Katayama T, Otsubo H, Ogasawara Y, Sekita T, et al. Prognostic factors of hemophagocytic syndrome in adults: Analysis of 34 cases. Eur J Haematol. 1997;59:247-53.
Lin TF, Ferlic-Stark LL, Allen CE, Kozinetz CA, Mcclain KL. Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality. Pediatr Blood Cancer. 2011;56:154-5. http://dx.doi.org/10.1002/pbc.22774.
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