Serological, molecular and virological analyses associated with yellow fever surveillance in Colombia
Keywords:
arboviruses, yellow fever, epidemiologic surveillance, enzyme-linked immunosorbent assay, reverse transcriptase polymerase chain reaction, virological analysis, Colombia
Abstract
Introduction. Yellow fever is an immunopreventable viral hemorrhagic fever that causes high morbidity and mortality in tropical and sub-tropical regions. In Colombia, approximately 5 million persons are at risk of becoming infected with yellow fever virus.Objective. The serological, molecular and virological analyses on the yellow fever surveillance samples were summarized in order to indicate the importance of appropriate and timely sampling in the process of case confirmation.
Materials and methods. The survey was based on samples received at the Arbovirus Laboratory, Virology Group, Instituto Nacional de Salud, Bogotá, during years 2006 to 2008. A total of 2,096 serum and tissue samples were tested for IgM antibodies against yellow fever by capture enzyme-linked immunosorbent assay, viral isolation-indirect fluorescence antibody technique, and reverse transcriptase-polymerase chain reaction. Positive samples were correlated with the clinical and epidemiological findings for their interpretation and confirmation.
Results. Of the 15 yellow fever cases confirmed in Colombia during 2006-2008 by histopathological techniques, 82% were confirmed at the Arbovirus Laboratory using serologic and molecular techniques. The positive cases were distributed in the rainforest region and in the foothills of the eastern chain of the Andes mountains.
Conclusion. The case distribution and prognosis illustrated the necessity of maintaining and strengthening the surveillance processes in those regions where the yellow fever virus is circulating. The cases must be recruited and diagnosed sufficiently early in order to use the above techniques in samples from live patients, in contrast to the histopathological procedures that require samples from fatal cases.
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References
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2. Groot H, Boshell J. Dengue, dengue hemorrágico y fiebre amarilla. En: Chalem F, Escandón JE, Campos J, Esguerra R, editores. Medicina interna. Bogotá: Doyma Andina, S.A.; 1992. p.1389-95.
3. Tesh RE. Viral hemorrhagic fevers of South America. Biomédica. 2002;22:287-95.
4. Oyewale T. Yellow fever in Africa: public health impact and prospects for control in the 21st century. Biomédica. 2002;22:178-93.
5. Organización Panamericana de la Salud. II Reunión conjunta de la Red de Vigilancia para Enfermedades Emergentes en el Amazonas y la Región del Cono Sur. Atlanta, Georgia, 2002. Rev Patol Trop. 2003;32(Supl.1):1-152.
6. Zanotto PM, Gould EA, Gao GF, Harvey PH, Holmes EC. Population dynamics of flaviviruses revealed by molecular phylogenies. Proc Natl Acad Sci USA. 1996;93:548-53.
7. Rodríguez G, Velandia M, Boshell J. Fiebre amarilla. La enfermedad y su control. Bogotá: Instituto Nacional de Salud; 2003. p. 47.
8. Monath TP, Ballinger ME, Miller BR, Salaun JJ. Detection of yellow fever viral RNA by nucleic acid hybridization and viral antigen by immunocytochemistry in fixed human liver. Am J Trop Med Hyg. 1989;40:663-8.
9. Ricaurte O, Sarmiento L, Caldas ML, Rodríguez G. Evaluación de un método inmunohistoquímico para el diagnóstico de la fiebre amarilla. Biomédica. 1993;13:15-9.
10. Deubel V, Huerre M, Cathomas G, Drouet MT, Wuscher N, LeGuenno B, et al. Molecular detection and characterization of yellow fever virus in blood and liver specimens of a non-vaccinated fatal human case. J Med Virol. 1997;53:212-7.
11. Pierre V, Drouet MT, Deubel V. Identification of mosquito-borne flavivirus sequences using universal primers and reverse transcription/polymerase chain reaction. Res Virol. 1994;145:93-104.
12. Méndez J, Rodríguez G, Bernal MP, Calvache D, Boshell J. Detección molecular del virus de la fiebre amarilla en muestras de suero de casos fatales humanos y en cerebros de ratón. Biomédica. 2003;23:232-8.
13. Monath TP. Yellow fever: Victor, Victoria? Conqueror, Conquest? Epidemics and research in the last forty years prospects for the future. Am J Trop Med Hyg. 1991;45:1-43.
14. Monath TP. Flaviviruses. En: Field's Virology. Second Edition. New York: Raven Press Ltd; 1990.
15. Groot H, Boshell J. Dengue, dengue hemorrágico y fiebre amarilla. En: Chalem F, Escandón J, Campos J, Esguerra R, editores. Medicina Interna. Tercera edición. Bogotá: Fundación Instituto de Reumatología e Inmunología; 1997. p. 645-51.
16. Tesh RE. A method for the isolation and identification of dengue virus using mosquito cell cultures. Am J Trop Med. 1979;28:1053.
17. Monath TP, Cropp CB, Muth DJ, Calisher CH. Indirect fluorescent test for the diagnosis of yellow fever. Trans R Soc Trop Med Hyg. 1981;75:282-6.
18. Martin DA, Muth DA, Brown T, Johnson AJ, Karabatsos N, Roehrig JT. Standardization if immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. J Clin Microbiol. 2000;38:1823-6.
19. Beaty BJ, Calisher CH, Shope RE. Arboviruses. In: Lennette EH, Lennette, DA, Lennette ET, editors. Diagnosis procedures for viral, rickettsial and chlamydial infections. Seventh edition. Washington, D.C.: American Public Health Association; 1995. p. 204-5.
20. Calisher CH, Meurman O, Brummer-Korvenkontio M, Halonen PE, Muth DJ. Sensitive enzyme immunoassay for detecting immunoglobulin M antibodies to Sinbdis virus and further evidence that Pogosta disease is caused by a Western equine encephalitis complex virus. J Clin Microbiol. 1985;22:566-71.
21. Monath TP, Nystrom RR. Detection of yellow fever virus in serum by enzyme immunoassay. Am J Trop Med Hyg. 1984;33:151-7.
22. Méndez J, Parra E, Neira M, Rey GJ. Detección por reacción en cadena de la polimerasa de transcriptasa reversa del virus de la fiebre amarilla en monos silvestres: una herramienta sensible para la vigilancia epidemiológica. Biomédica. 2007;27:461-7.
23. Benenson AS. Paludismo (Malaria). En: Manual para el control de las enfermedades transmisibles. Decimosexta edición. Publicación Científica No. 564. Washington, D.C.: Organización Panamericana de la Salud; 1997. p. 350-9.
How to Cite
1.
Múnera GI, Méndez JA, Rey GJ. Serological, molecular and virological analyses associated with yellow fever surveillance in Colombia. Biomed. [Internet]. 2010 Sep. 30 [cited 2025 Apr. 4];30(3):345-52. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/268
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2010-09-30
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