Association between genetic ancestry and EDAR rs3827760 genotypes in Latin American populations
Abstract
Introduction. The EDAR (Ectodysplasin A Receptor) gene is associated with the development of ectodermal structures. The rs3827760 variant is highly frequent in East Asian and Native American populations, and this study analyzes its relationship with genetic ancestry proportions in a Latin American population sample.
Objective. To analyze how genetic ancestry proportions influence the distribution of SNP rs3827760 genotypes of the EDAR gene in Latin American populations.
Materials and methods. Genetic ancestry proportions were estimated using a panel of 446 ancestry-informative SNPs, applying the STRUCTURE program and univariate and multivariate logistic regression models.
Results. Native American ancestry proportions showed a significant positive association with the prevalence of rs3827760 GG genotypes, while European ancestry showed a negative association.
Conclusion. Native American and European genetic ancestry proportions influence the distribution of SNP rs3827760 genotypes of the EDAR gene in Latin American populations.
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