Effect of periodontal therapy on the subgingival microbiota in preeclamptic patients
Abstract
Introduction. Few studies have described subgingival microbiota in pregnant women with mild preeclampsia.
Objective. Clinical periodontal and subgingival microbiota changes were identified in pregnant women with mild preeclampsia after periodontal treatment.
Materials and methods. In a secondary analysis of a randomized clinical trial, 57 preeclamptic women were studied at Hospital Universitario del Valle in Cali, Colombia. Thirty one women were randomized to the periodontal intervention group (subgingival scaling and planing ultrasonic and manual) during pregnancy and 26 to the control group (supragingival prophylaxis). Periodontal clinical parameters and subgingival microbiota were characterized at the time of acceptance into the study and again atpostpartum. Eight periodontopathic bacteria and 2 herpesviruses were assessed by polymerase chain reaction. Chi-square, McNemar or Student’s t tests were used, with a significance level of p≤0.05.
Results. Both groups were comparable in the clinical and microbiological variables at baseline. Periodontal treatment reduced the average pocket depth in the intervention group from 2.4±0.3 to 2.3±0.2 mm (p<0.001) and in control group 2.6±0.4 to 2.44±0.4 mm, (p<0.001) and bleeding index 16.4±1.5% to 7.9±0.7% in the intervention group(p<0.001) and 17.1±1.8% to 10±0.9% in the control group (p=0.002). The frequency of detection of microorganisms did not differ significantly between groups.
Conclusion. Scaling/root planning and supragingival prophylaxis significantly reduced the probing depth and gingival bleeding index. Periodontal treatment was not more effective than prophylaxis in reducing periodontopathic organisms or herpesvirus.
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References
Boggess KA, Lieff S, Murtha AP, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol. 2003;101:227-31. doi: http://dx.doi.org/10.1016/S0029-7844(02)02314-1
Contreras A, Herrera JA, Soto JE, Arce RM, Jaramillo A, Botero JE. Periodontitis is associated with preeclampsia in pregnant women. J Periodontol. 2006;77:182-8. doi: http://dx.doi.org/10.1902/jop.2006.050020
Conde-Agudelo A, Villar J, Lindheimer M. Maternal infection and risk of preeclampsia: Systematic review and metaanalysis. Am J Obstet Gynecol. 2008;198:7-22. doi: http://dx.doi.org/10.1016/j.ajog.2007.07.040
Offenbacher S, Boggess KA, Murtha AP, Jared HL, Lieff S, McKaig RG, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol. 2006;107:29-36. doi: http://dx.doi.org/10.1097/01.AOG.0000190212.87012.96
Contreras A, Botero JE, Jaramillo A, Soto JE, Vélez S, Herrera JA. Efectos del tratamiento periodontal sobre el parto prematuro y el bajo peso al nacer en mujeres con preeclampsia: ensayo clínico controlado. Rev Odont Mex. 2010;14:226-30.
Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4:1-6. doi: http://dx.doi.org/10.1902/annals.1999.4.1.1
Boom R, Sol CJ, Salimans M. Rapid and simple method for purification of nucleic acids. J Clin Microbiol. 1990;28:495-503. PMid:1691208 PMCid:269651
Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol. 1996;11:266-73. doi: http://dx.doi.org/10.1111/j.1399-302X.1996.tb00180.x
Parra B, Slots J. Detection of human viruses in periodontal pockets using polymerase chain reaction. Oral Microbiol Immunol. 1996;11:289-93.
doi: http://dx.doi.org/10.1111/j.1399-302X.1996.tb00183.x
Herrera JA, Vélez S, Molano R, Medina V, Botero JE, Parra B, et al. Periodontal intervention effects on pregnancy outcomes in women with preeclampsia. Colomb Med. 2009;40:177-84.
Ruma M, Boggess K, Moss K, Jared H, Murtha A, Beck J, et al. Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol. 2008;198:389.e1-5.
Barak S, Oettinger-Barak O, Machtei EE, Sprecher H, Ohel G. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol. 2007;78:670-6. doi: http://dx.doi.org/10.1902/jop.2007.060362
Kunnen A, Blaauw J, van Doormaal JJ, van Pampus MG, van der Schans CP, Aarnoudse JG, et al. Women with a recent history of early-onset pre-eclampsia have a worse periodontal condition. J Clin Periodontol. 2007;34:202-7. doi: http://dx.doi.org/10.1111/j.1600-051X.2006.01036.x
López NJ, Smith PC, Gutiérrez J. Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: A randomized controlled trial. J Periodontol. 2002;73:911-24. doi: http://dx.doi.org/10.1902/jop.2002.73.8.911
López NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD. Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol. 2006;33:648-60. doi: http://dx.doi.org/10.1111/j.1600-051X.2006.00957.x
Han YW. Oral health and adverse pregnancy outcomes -what’s next? J Dent Res. 2011;90:289-93. doi: http://dx.doi.org/10.1177/0022034510381905
Loos BG. Systemic markers of inflammation in periodontitis. J Periodontol. 2005;76:2106-15. doi: http://dx.doi.org/10.1902/jop.2005.76.11-S.2106
López NJ, Smith PC, Gutiérrez J. Higher risk of preterm birth and low birth weight in women with periodontal disease. J Dent Res. 2002;81:58-63. doi: http://dx.doi.org/10.1177/154405910208100113
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