Middle ear adenoma
Keywords:
Adenoma/pathology, ear, middle, immunohistochemistry, differential, diagnosis, carcinoid tumor
Abstract
Middle ear neoplasms are rare lesions and difficult to diagnose due to limited information about their biology and the lack of standard criteria for their analysis. Herein, a middle ear neoplasm is described that became apparent because of its appearance in the external ear duct as it protruded from the middle ear through the eardrum. Following resection, the specimen was determined to be a benign epithelial tumor. Absence of adequate clinical information complicated the diagnosis; therefore,histochemistry and immunohistochemistry analyses were necessary to reach the final diagnosis of middle ear adenoma. Diagnostic criteria are proposed to properly diagnose these types of lesions.Downloads
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References
1. Stanley MW, Horwitz CA, Levinson RM, Sibley RK. Carcinoid tumors of the middle ear. Am J Clin Pathol. 1987;87:592-600.
2. Berns S, Pearl G. Middle ear adenoma. Arch Pathol Lab Med. 2006;130:1067-9.
3. Wassef M, Kanavaros P, Polivka M, Nemeth J, Monteil JP, Frachet B, et al. Middle ear adenoma. A tumor displaying mucinous and neuroendocrine differentiation. Am J Surg Pathol. 1989;13:838-47.
4. Orendorz-FrÄ czkowska K, Jaworska M, Gawron W, Badowski R. Middle ear ceruminous adenoma as a rare cause of hearing loss and vertigo: Case reports. Auris Nasux Larinx. 2005;32:393-7.
5. Gunduz M, Yamanaka N, Saito T, Kuki K, Yokoyama M, Nakamine H. Middle ear adenoma with neuroendocrine differentiation. Auris Nasus Larynx. 2000;27:73-6.
6. Hale RJ, McMahon RFT, Whittaker JS. Middle ear adenoma: Tumour of mixed mucinous and neuroendocrine differentiation. J Clin Pathol. 1991;44:652-4.
7. Ribé A, Fernández PL, Ostertarg H, Clarós P, Bombí JA, Palacín A, et al. Middle ear adenoma (MEA): A report of two cases, one with predominant “plasmocitoid” features. Histopathology. 1997;30:359-64.
8. Mills SE, Fechner RE. Middle ear adenoma: A cytologically uniform neoplasm displaying a variety of architectural patterns. Am J Surg Pathol. 1984;8:677-85.
9. Torske KR, Thompson LD. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 2002;15:543-55.
10. Prophet EB, Mills B, Arrington JB, Sobin LH. Laboratory methods in histotechnology. Washington DC: Armed Forces Institute of Pathology/American Registry of Pathology; 1992. p. 151, 156-60, 219-20.
11. Rosai J. Rosai and Ackerman’s surgical pathology. 9th edition. Philadelphia: Mosby-Elsevier Inc.; 2004. p. 2774, 2776-7.
12. Wenig BM. The ear. En: Weidner N, editor. Modern surgical pathology. 1st edition. New York: Saunders-Elsevier Science; 2003. p. 285-6.
13. Mills SE. Tumors of the upper aerodigestive tract and ear. Atlas of tumor pathology. 3rd series. Fascicle 26. Washington D.C.: Armed Forces Institute of Pathology; 2000. p. 401-6, 431-4.
14. Wenig BM. The ear. In: Mills SE, editor. Sternberg’s diagnostic surgical pathology. 4th edition. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 1053-4, 1058-60.
15. Gaffey MJ, Mills SE, Fechner RE, Intemann SR, Wick MR. Aggressive Papillary middle-ear tumor. A clinicopathologic entity distinct from middle-ear adenoma. Am J Surg Pathol. 1988;12: 790-7.
16. Lassaletta L, Patrón M, Olóriz J, Pérez R, Gavilán J. Avoiding misdiagnosis in ceruminous gland tumours. Auris Nasux Larinx. 2003;30:287-90.
17. Iqbal A, Newman P. Ceruminous gland neoplasia. Br J Plast Surg. 1998;51:317-20.
18. Thompson LD, Nelson BL, Barnes EL. Cerominous adenomas. A clinicopathologic study of 41 cases with a review of literature. Am J Surg Pathol. 2004;28:308-18.
19. Kuwabara H, Haginomori SI, Takamaki A, Ito K, Takenaka H, Kurisu Y, et al. Lipomatous pleomorphic adenoma of the cerominous gland. Pathol Int. 2006;56:51-3.
20. Conlin PA, Mira JL, Graham SC, Kaye KS, Cordero J. Ceruminous gland adenoid cystic carcinoma with contralateral metastasis and the brain. Arch Pathol Lab Med. 2002;126:87-9.
2. Berns S, Pearl G. Middle ear adenoma. Arch Pathol Lab Med. 2006;130:1067-9.
3. Wassef M, Kanavaros P, Polivka M, Nemeth J, Monteil JP, Frachet B, et al. Middle ear adenoma. A tumor displaying mucinous and neuroendocrine differentiation. Am J Surg Pathol. 1989;13:838-47.
4. Orendorz-FrÄ czkowska K, Jaworska M, Gawron W, Badowski R. Middle ear ceruminous adenoma as a rare cause of hearing loss and vertigo: Case reports. Auris Nasux Larinx. 2005;32:393-7.
5. Gunduz M, Yamanaka N, Saito T, Kuki K, Yokoyama M, Nakamine H. Middle ear adenoma with neuroendocrine differentiation. Auris Nasus Larynx. 2000;27:73-6.
6. Hale RJ, McMahon RFT, Whittaker JS. Middle ear adenoma: Tumour of mixed mucinous and neuroendocrine differentiation. J Clin Pathol. 1991;44:652-4.
7. Ribé A, Fernández PL, Ostertarg H, Clarós P, Bombí JA, Palacín A, et al. Middle ear adenoma (MEA): A report of two cases, one with predominant “plasmocitoid” features. Histopathology. 1997;30:359-64.
8. Mills SE, Fechner RE. Middle ear adenoma: A cytologically uniform neoplasm displaying a variety of architectural patterns. Am J Surg Pathol. 1984;8:677-85.
9. Torske KR, Thompson LD. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 2002;15:543-55.
10. Prophet EB, Mills B, Arrington JB, Sobin LH. Laboratory methods in histotechnology. Washington DC: Armed Forces Institute of Pathology/American Registry of Pathology; 1992. p. 151, 156-60, 219-20.
11. Rosai J. Rosai and Ackerman’s surgical pathology. 9th edition. Philadelphia: Mosby-Elsevier Inc.; 2004. p. 2774, 2776-7.
12. Wenig BM. The ear. En: Weidner N, editor. Modern surgical pathology. 1st edition. New York: Saunders-Elsevier Science; 2003. p. 285-6.
13. Mills SE. Tumors of the upper aerodigestive tract and ear. Atlas of tumor pathology. 3rd series. Fascicle 26. Washington D.C.: Armed Forces Institute of Pathology; 2000. p. 401-6, 431-4.
14. Wenig BM. The ear. In: Mills SE, editor. Sternberg’s diagnostic surgical pathology. 4th edition. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 1053-4, 1058-60.
15. Gaffey MJ, Mills SE, Fechner RE, Intemann SR, Wick MR. Aggressive Papillary middle-ear tumor. A clinicopathologic entity distinct from middle-ear adenoma. Am J Surg Pathol. 1988;12: 790-7.
16. Lassaletta L, Patrón M, Olóriz J, Pérez R, Gavilán J. Avoiding misdiagnosis in ceruminous gland tumours. Auris Nasux Larinx. 2003;30:287-90.
17. Iqbal A, Newman P. Ceruminous gland neoplasia. Br J Plast Surg. 1998;51:317-20.
18. Thompson LD, Nelson BL, Barnes EL. Cerominous adenomas. A clinicopathologic study of 41 cases with a review of literature. Am J Surg Pathol. 2004;28:308-18.
19. Kuwabara H, Haginomori SI, Takamaki A, Ito K, Takenaka H, Kurisu Y, et al. Lipomatous pleomorphic adenoma of the cerominous gland. Pathol Int. 2006;56:51-3.
20. Conlin PA, Mira JL, Graham SC, Kaye KS, Cordero J. Ceruminous gland adenoid cystic carcinoma with contralateral metastasis and the brain. Arch Pathol Lab Med. 2002;126:87-9.
How to Cite
1.
Medina EA. Middle ear adenoma. Biomed. [Internet]. 2009 Sep. 1 [cited 2025 Apr. 4];29(3):348-53. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/5
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