Water-induced dermatosis: Aquagenic keratoderma. A case report
Abstract
Aquagenic keratoderma is a benign entity that is characterized by producing whitish or translucent papules a few seconds after contact with water.
We present the case of a 16-year-old patient with multiple asymptomatic confluent papules that appeared on both hand palms after contact with water and which disappeared after drying. The histopathological findings in a skin biopsy after water exposure showed changes in the superficial layers of the stratum corneum and dilatation of sweat gland ducts.
This entity of unknown etiology has been related to neuronal and eccrine gland dysfunction. Recently it has been associated with alterations of aquaporins. The “hand-in-the-bucket” sign is a simple useful clinical tool for diagnosis, as histopathological findings may be nonspecific. Topical treatments include barrier mechanisms and botulinum toxin.
Downloads
References
English JC, McCollough ML. Transient reactive papulotranslucent acrokeratoderma. J Am Acad Dermatol. 1996;34:686-7. https://doi.org/10.1016/S0190-9622(96)80087-9
Tchernev G, Semkova K, Cardoso JC, Ananiev JJ, Wollina U. Aquagenic keratoderma. Two new case reports and a new hypothesis. Indian Dermatol Online J. 2014;5:30-3. https://doi.org/10.4103/2229-5178.126025
Ertürk-Özdemir E, Özcan D, Seçkin D. Acquired aquagenic syringeal acrokeratoderma: A case series of 10 patients. Australas J Dermatol. 2015;56:e43-5. https://doi.org/10.1111/ajd.12122
Lafuente-Urrez RF, Pérez-Pelegay J, Corredera-Carrión C. Queratodermia acuagénica: aportación de dos nuevos casos. Piel. 2014;29:60-2. https://doi.org/10.1016/j.piel.2013.06.003
Yan AC, Aasi SZ, Alms WJ, James WD, Heymann WR, Paller AS, et al. Aquagenic palmoplantar keratoderma. J Am Acad Dermatol. 2001;44:696-9. https://doi.org/10.1067/mjd.2001.113479
Qing X. Aquagenic acrokeratoderma: Case report with no involvement of the palms. Int J Dermatol. 2012;51:1388-403. https://doi.org/10.1111/j.1365-4632.2010.04803.x
Rongioletti F, Tomasini C, Crovato F, Marchesi L. Aquagenic (pseudo) keratoderma: A clinical series with new pathological insights. Br J Dermatol. 2012;167:575-82. https://doi.org/10.1111/j.1365-2133.2012.11003.x
Houle M-C, Al Dhaybi R, Benohanian A. Unilateral aquagenic keratoderma treated with botulinum toxin A. J Dermatol Case Rep. 2010;4:1-5. https://doi.org/10.3315/jdcr.2010.1045
Pardo J, Sánchez-Motilla JM, Latasa JM. Queratodermia acuagénica de características atípicas. Actas Dermosifiliogr. 2005;96:540-2. https://doi.org/10.1016/S0001-7310(05)73130-6
Peña-Romero AG, Toussaint-Caire S, Charli-Joseph Y, Dela Barreda-Becerril F, Domínguez-Cherit J. From classical to unusual: Report on 5 cases of transient reactive aquagenic pseudokeratoderma and review of the literature. Am J Dermatopathol. 2017;39:935-42. https://doi.org/10.1097/DAD.0000000000000815
Nazik H, Nazik S, Çoban FG, Demir B. Sporadic and familial cases of aquagenic keratoderma. J Dermatol Case Rep. 2016;10:10-3. https://doi.org/10.3315/jdcr.2016.1223
Kabashima K, Shimauchi T, Kobayashi M, Fukamachi S, Kawakami C, Ogata M, et al. Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms. J Am Acad Dermatol. 2008;59:S28-32. https://doi.org/10.1016/j.jaad.2008.04.023
Garçon-Michel N, Roguedas-Contios A-M, Rault G, Le Bihan J, Ramel S, Revert K, et al. Frequency of aquagenic palmoplantar keratoderma in cystic fibrosis: A new sign of cystic fibrosis? Br J Dermatol. 2010;163:162-6. https://doi.org/10.1111/j.1365-2133.2010.09764.x
Katz KA, Yan AC, Turner ML. Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the ΔF508 CFTR mutation. Arch Dermatol. 2005;141:621-4. https://doi.org/10.1001/archderm.141.5.621
Gündüz Ö, Özsaraç K, Ercin ME. Aquagenic palmar wrinkling induced by combined use of salazopyrin and indomethacin. Case Rep Dermatol. 2013;5:21-6. https://doi.org/10.1159/000346744
Pastor MA, González L, Kilmurray L, Bautista P, López A, Puig AM. Queratodermia acuagénica. Actas Dermosifiliogr. 2008;99:399-406. https://doi.org/10.1016/S0001-7310(08)74700-8
Baldwin BT, Prakash A, Fenske NA, Messina JL. Aquagenic syringeal acrokeratoderma: Report of a case with histologic findings. J Am Acad Dermatol. 2006;54:899-902. https://doi.org/10.1016/j.jaad.2005.09.007
Errichetti E, Piccirillo A. Aquagenic keratoderma treated with tap water iontophoresis. Indian J Dermatol. 2015;60:212. https://doi.org/10.4103/0019-5154.152568
Some similar items:
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
