Collapsing glomerulonephritis with podocyte markers in hemophagocytic syndrome secondary to hepatosplenic T-cell lymphoma
Abstract
The hemophagocytic syndrome is a serious clinical-histological entity secondary to different diseases. Collapsing glomerulonephritis is a proliferative podocytopathy that usually has an unfavorable renal prognosis. We present a case in which both entities were associated, which is an infrequent form of hepatosplenic T-cell lymphoma. In addition, we review the role of the markers of podocyte dedifferentiation in this glomerulopathy and its pathophysiology and treatment.
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Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1993;15:92-8.
Larroche C, Spivak JL. Pathogenesis of hemophagocytic syndrome. Autoimmune Rev. 2004;3:69-75. https://doi.org/10.1016/S1568-9972(03)00091-0
D´Agati VD, Fogo AB, Bruijin JA, Jenette JC. Pathologic classification of focal segmental glomerulosclerosis: A working proposal. Am J Kidney Dis. 2004;43:368-82. https://doi.org/10.1053/j.ajkd.2003.10.024
Verbsky JM, Grossman WJ. Hemophagocytic lymphohistiocytosis: Diagnosis, pathophysiology, treatment, and future perspectives. Ann Med. 2006;38:20-31. https://doi.
org/10.1080/07853890500465189
Kumukura S, Murakawa Y. Clinical characteristics and treatment outcomes of autoimmune-associated hemophagocytic syndrome in adults. Arthritis Rheumatol. 2014;66:2297-307. https://doi.org/10.1002/art.38672
Trottestam H, Horne A, Arico M, Egeler RM, Filipovich AH, Gadner H, et al. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: Long-term results of the HLH-94 treatment protocol. Blood. 2011;118:4577-84. https://doi.org/10.1182/blood-2011-06-356261
Aulagnon F, Lapidus N, Canet E, Galicier L, Boutboul D, Peraldi MN, et al. Acute kidney injury in adults with hemophagocytic lymphohistiocytosis. Am J Kidney Dis. 2015;65:851-9. https://doi.org/10.1053/j.ajkd.2014.10.012
Karras A. What nephrologists need to know about hemophagocytic syndrome. Nat Rev Nephrol. 2009;5:329-36. https://doi.org/10.1038/nrneph.2009.73
Málaga-Dieguez L, Ming W, Trachtman H. Direct reversible kidney injury in familial hemophagocytic lymphohistiocytosis type 3. J Am Soc Nephrol. 2015;26:1777-80. https://doi.org/10.1681/ASN.2014111090
Thaunat O, Delahoisse M, Fakhouri F, Martínez F, Stephan JL, Noël LH, et al. Nephrotic syndrome associated with hemophagocytic syndrome. Kidney Int. 2006;69:1892-
https://doi.org/10.1038/sj.ki.5000352
Esmaili H, Mostafidi E, Mehramuz B, Ardalan M, Mohajel-Shoja M. An update on renal involvement in hemophagocytic syndrome (macrophage activation syndrome). J Nephropathol. 2016;5:8-14. https://doi.org/10.15171/jnp.2016.02
Santoriello D, Hogan H, DÁgati VD. Hemophagocytic syndrome with histiocytic glomerulopathy and intraglomerular hemophagocytosis. Am J Kidney Dis. 2016;67:978-83.
https://doi.org/10.1053/j.ajkd.2015.11.017
Ponticelli C, Alberighi OD. Haemophagocytic syndrome--a life-threatening complication of renal transplantation. Nephrol Dial Transplant. 2009;24:2623-7. https://doi.org/10.1093/ndt/gfp282
Raffray L, Couzi L, Viallard JF, Pellegrin JL, Augis V, Vernant JP, et al. Mycophenolate mofetil: A possible cause of hemophagocytic syndrome following renal transplantation? Am J Transplant. 2010;10:2378-9. https://doi.org/10.1111/j.1600-6143.2010.03254.x
Nichols B, Jog P, Lee JH, Blackler D, Wilmot M, Dágit V, et al. Innate immunity pathways regulate the nephropathy gene apolipoprotein L1. Kidney Int. 2015;87:332-42. https://doi.org/10.1038/ki.2014.270
Genovese G, Tonna SJ, Know AU, Appel GB, Katz A, Bernhardy AJ, et al. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int. 2010;78:698-704. https://doi.org/10.1038/ki.2010.251
Redondo-Pachón MD, Ortega-Salas R, Moyano-Peregrin C, López-Andreu M, Espinosa-Hernández M, Romera-Segorbe A, et al. Marcadores de desdiferenciacion podocitaria en un paciente con glomerulonefritis colapsante.Nefrología. 2010;30:360-6. https://doi.org/10.3265/Nefrologia.pre2010.Mar.10325
Albaqumi M, Barisoni L. Current views on collapsing glomerulopathy. J Am Soc Nephrol. 2008;19:1276-81. https://doi.org/10.1681/ASN.2007080926
Koukouritaki SB, Vardaki EA, Papakonstanti EA, Lianos E, Stournaras C, Emmanouel DS. TNF-alpha induces actin cytoskeleton reorganization in glomerular epithelial cells involving tyrosine phosphorylation of paxillin and focal adhesion kinase. Mol Med. 1999;5:382-92.
Markowitz GS, Nasr SH, Stokes MB, D´Agati VD. Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2010;5:607-15. https://doi.org/10.2215/CJN.07311009
Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003;83:253-307. https://doi.org/10.1152/physrev.00020.2002
Shankland SJ, Eitner F, Hudkins KL, Goodpaster T, D´Agati V, Alpers CE. Differential expression of cyclindependent kinase inhibitors in human glomerular disease: Role in podocyte proliferation and maturation. Kidney Int. 2000;58:674-83. https://doi.org/10.1046/j.1523-1755.2000.00213.x
Barisona L, Nelson PJ. Collapsing glomerulopathy: An inflammatory podocytopathy? Curr Opin Nephrol Hypertens. 2007;16:192-5. https://doi.org/10.1097/MNH.0b 013e
b726b
Schwimmer JA, Markowitz GS, Valeri A, Appel GB. Collapsing glomerulopathy. Semin Nephrol. 2003;23:209-18.
Grcevska L, Polenakovik M. Collapsing glomerulopathy: Clinical characteristic and follow-up. Am J Kidney Dis. 1999;33:652-57. https://doi.org/10.1053/snep.2003.50019
Kashgary A, Sontrop JM, Li L, Al-Jaishi AA, Habibullah ZN, Alsolaimani R. The role of plasma exchange in treating post-transplant focal segmental glomerulosclerosis: A systematic review and meta-analysis of 77 case-reports and case-series. BMC Nephrol. 2016;17:104. https://doi.org/10.1186/s12882-016-0322-7
Asci G, Toz H, Ozkahya M, Cagirgan S, Duman S, Sezis M, et al. High-dose immunoglobulin therapy in renal transplant recipients with hemophagocytic histiocytic syndrome. J Nephrol. 2006;19:322-6.
Ferreri AJM, Govi S, Pilari SA. Hepatosplenic gamma-delta T-cell lymphoma. Crit Rev Oncol Hematol. 2012;83:283-292. https://doi.org/10.1016/j.critrevonc.2011.10.001
Han AR, Lee HR, Park BB, Hwang IG, Park S, Lee SC, et al. Lymphoma-associated hemophagocytic syndrome: Clinical features and treatment outcome. Ann Hematol. 2007;86:493-8. https://doi.org/10.1007/s00277-007-0278-6
Egües-Dubuc C, Aldasoro-Cáceres V, Uriarte-Ecenarro M, Errazquin-Aguirre N, Hernando-Rubio I, Meneses-Villalba CF, et al. Síndrome de activación macrofágica secundario a enfermedades autoinmunes, hematológicas, infecciosas y oncológicas. Serie de 13 casos clínicos y una revisión bibliográfica. Reumatol Clin. 2015;11:139-43. https://doi.org/10.1016/j.reuma.2014.06.007
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