Autoimmune encephalitis associated to antibodies against the N-methyl-D-aspartate receptor: Report of two cases
Abstract
Anti-N-methyl-D-aspartate receptor encephalitis is a neurological syndrome that is more common in young women and is often associated with ovarian teratoma. It is characterized by acute general unspecific symptoms that evolve to neurological deterioration, psychosis and seizures. In its more advanced stage it is associated with abnormal movements and dysautonomia.
We report two cases in women of 23 and 12 years of age. Given its low incidence, we present the clinical exercise that led to their diagnoses and the treatment options employed.
Downloads
References
Tsien JZ. Building a brainier mouse. Sci Am. 2000;282:62-8. http://dx.doi.org/10.1038/scientificamerican0400-62
Tüzün E, Dalmau J. Limbic encephalitis and variants: Classification, diagnosis and treatment. Neurologist. 2007;13:261-71. http://dx.doi.org/10.1097/NRL.0b013e31813e34a5
Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies. Lancet
Neurol. 2008; 7:1091-8. http://dx.doi.org/10.1016/S1474-4422(08)70224-2
Florance NR, Davis RL, Lam C, Szperka C, Zhou L, Ahmad S, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009;66:11-8. http://dx.doi.org/10.1002/ana.21756
Dalmau J, Tüzün E, Wu H, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25-36. http://dx.doi.org/10.1002/ana.21050
Day GS, High SM, Cot B, Tang-Wai DF. Anti-NMDA-receptor encephalitis: Case report and literature review of an underrecognized condition. J Gen Intern Med. 2011;26:811-6. http://dx.doi.org/10.1007/s11606-011-1641-9
Miya K, Takahashi Y, Mori H. Anti-NMDAR autoimmune encephalitis. Brain Dev. 2014;36:645-52. http://dx.doi.org/10.1016/j.braindev.2013.10.005
Suárez DV, Rojas JP, Castillo GE, Díaz E, Montero FJ. Encefalitis por anticuerpos contra el receptor N-metil D-aspartato (NMDAR) en pediatría. Reporte de caso y
revisión de la literatura. Acta Neurológica Colombiana. 2014;30:193-9.
De Broucker T, Martínez-Almoyna L. Anti-NMDA-receptor encephalitis. Med Mal Infect. 2010;40:1-5. http://dx.doi.org/10.1016/j.medmal.2009.10.013
Iizuka T, Sakai F, Ide T, Monzen T, Yoshii S, Iigaya M, et al. Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal. Neurology. 2008;70:504-11. http://dx.doi.org/10.1212/01.wnl.0000278388.90370.c3
Sansing LH, Tüzün E, Ko MW, Baccon J, Lynch DR, Dalmau J. A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol. 2007;3:291-6. http://dx.doi.org/10.1038/ncpneuro0493
Kruse JL, Jeffrey JK, Davis MC, Dearlove J, IsHak WW, Brooks JO. Anti-N-methyl-D-aspartate receptor encephalitis: A targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management. Ann Clin Psychiatry. 2014;26:111-9.
Johnson N, Henry C, Fessler AJ, Dalmau J. Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus. Neurology. 2010;75:1480-2. http://dx.doi.org/10.1212/WNL.0b013e3181f8831a
Lazar-Molnar E, Tebo AE. Autoimmune NMDA receptor encephalitis. Clin Chim Acta. 2015;438:90-7. http://dx.doi.org/10.1016/j.cca.2014.08.010
Jones KC, Benseler SM, Moharir M. Anti–NMDA receptor encephalitis. Neuroimaging Clin. 2013;23:309-20. http://dx.doi.org/10.1016/j.nic.2012.12.009
Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS, et al. N-methyl-D-aspartate antibody encephalitis: Temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain J Neurol. 2010;133:1655-67. http://dx.doi.org/10.1093/brain/awq113
Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 2004;75:1135-40. http://dx.doi.org/10.1136/jnnp.2003.034447
Dalmau J, Lancaster E, Martínez-Hernández E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10:63-74. http://dx.doi.org/10.1016/S1474-4422(10)70253-2
Susan Byrne ML. N-methyl-D-aspartate receptor antibody encephalitis: How much treatment is enough? Dev Med Amp Child Neurol. 2014;57:14-5. http://dx.doi.org/10.1111/dmcn.12559
Ramanathan S, Mohammad SS, Brilot F, Dale RC. Autoimmune encephalitis: Recent updates and emerging challenges. J Clin Neurosci. 2014;21:722-30. http://dx.doi.
org/10.1016/j.jocn.2013.07.017
Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: An observational cohort study. Lancet Neurol. 2013;12:157-65. http://dx.doi.org/10.1016/S1474-4422(12)70310-1
Peery HE, Day GS, Dunn S, Fritzler MJ, Prüss H, De Souza C, et al. Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmun
Rev. 2012;11:863-72. http://dx.doi.org/10.1016/j.autrev.2012.03.001
Some similar items:
- Doracelly Hincapié, Marcela Acevedo, María Cristina Hoyos, Jesús Ochoa, Catalina González, Paula Andrea Pérez, Adriana Molina, Blanca Isabel Restrepo, Marcela Arrubla, Adriana Patricia Echeverri, Rita Elena Almanza, Luz Denise González, Eduardo Santacruz-Sanmartín, Norma Elena Orrego, Daniel Arango, Aura María Gutiérrez, Olga Lucía Londoño, Luz Maribel Toro, Mónica Ríos, Oscar Villada, Luz Aida Mejía, Paola Andrea Arenas, Diego García, Elkin Osorio, Serosurveillance for vaccine-preventable diseases: A look inside the pertussis experience , Biomedica: Vol. 39 No. Supl. 2 (2019): Enfermedades transmisibles en el trópico, agosto
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
