Polymorphism of TNF-alpha in autoimmunity and tuberculosis.
Keywords:
tumor necrosis factor, polymorphism, rheumatoid arthritis, systemic lupus erythematosus, Sjögren?s syndrome, autoimmunity, tuberculosis
Abstract
Tumor necrosis factor alpha (TNF-alpha) has been incriminated in several autoimmune and infectious diseases. The influence of TNF-alpha -308 polymorphism was examined in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS) and tuberculosis. Genomic DNA from patients with RA (N=165), SLE (N=118), pSS (N=67), tuberculosis (N=138), as well as ethnic-matched controls (N=419) were characterized for the TNF-alpha -308 genetic polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. TNF2 allele was associated with RA (OR: 1.6, C.I.95% 1.2-2.3, p=0.008), SLE (OR: 2.3, 95%C.I. 1.6-3.3, pDownloads
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1.
Correa PA, Gómez LM, Anaya JM. Polymorphism of TNF-alpha in autoimmunity and tuberculosis. Biomed. [Internet]. 2004 Jun. 1 [cited 2025 Apr. 12];24(Sup1):43-51. Available from: https://revistabiomedicaorg.biteca.online/index.php/biomedica/article/view/1301
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Published
2004-06-01
Section
Original articles
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